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Targeted nanoconjugate co-delivering siRNA and tyrosine kinase inhibitor to KRAS mutant NSCLC dissociates GAB1-SHP2 post oncogene knockdown
A tri-block nanoparticle (TBN) comprising of an enzymatically cleavable porous gelatin nanocore encapsulated with gefitinib (tyrosine kinase inhibitor (TKI)) and surface functionalized with cetuximab-siRNA conjugate has been synthesized. Targeted delivery of siRNA to undruggable KRAS mutated non-sma...
Autores principales: | Srikar, R., Suresh, Dhananjay, Zambre, Ajit, Taylor, Kristen, Chapman, Sarah, Leevy, Matthew, Upendran, Anandhi, Kannan, Raghuraman |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4987653/ https://www.ncbi.nlm.nih.gov/pubmed/27530552 http://dx.doi.org/10.1038/srep30245 |
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