Comparative Analysis of piggyBac, CRISPR/Cas9 and TALEN Mediated BAC Transgenesis in the Zygote for the Generation of Humanized SIRPA Rats

BAC transgenic mammalian systems offer an important platform for recapitulating human gene expression and disease modeling. While the larger body mass, and greater genetic and physiologic similarity to humans render rats well suited for reproducing human immune diseases and evaluating therapeutic st...

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Detalles Bibliográficos
Autores principales: Jung, Chris J., Ménoret, Séverine, Brusselle, Lucas, Tesson, Laurent, Usal, Claire, Chenouard, Vanessa, Remy, Séverine, Ouisse, Laure-Hélène, Poirier, Nicolas, Vanhove, Bernard, de Jong, Pieter J., Anegon, Ignacio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4987655/
https://www.ncbi.nlm.nih.gov/pubmed/27530248
http://dx.doi.org/10.1038/srep31455

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