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SAbPred: a structure-based antibody prediction server
SAbPred is a server that makes predictions of the properties of antibodies focusing on their structures. Antibody informatics tools can help improve our understanding of immune responses to disease and aid in the design and engineering of therapeutic molecules. SAbPred is a single platform containin...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4987913/ https://www.ncbi.nlm.nih.gov/pubmed/27131379 http://dx.doi.org/10.1093/nar/gkw361 |
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author | Dunbar, James Krawczyk, Konrad Leem, Jinwoo Marks, Claire Nowak, Jaroslaw Regep, Cristian Georges, Guy Kelm, Sebastian Popovic, Bojana Deane, Charlotte M. |
author_facet | Dunbar, James Krawczyk, Konrad Leem, Jinwoo Marks, Claire Nowak, Jaroslaw Regep, Cristian Georges, Guy Kelm, Sebastian Popovic, Bojana Deane, Charlotte M. |
author_sort | Dunbar, James |
collection | PubMed |
description | SAbPred is a server that makes predictions of the properties of antibodies focusing on their structures. Antibody informatics tools can help improve our understanding of immune responses to disease and aid in the design and engineering of therapeutic molecules. SAbPred is a single platform containing multiple applications which can: number and align sequences; automatically generate antibody variable fragment homology models; annotate such models with estimated accuracy alongside sequence and structural properties including potential developability issues; predict paratope residues; and predict epitope patches on protein antigens. The server is available at http://opig.stats.ox.ac.uk/webapps/sabpred. |
format | Online Article Text |
id | pubmed-4987913 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Oxford University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-49879132016-08-22 SAbPred: a structure-based antibody prediction server Dunbar, James Krawczyk, Konrad Leem, Jinwoo Marks, Claire Nowak, Jaroslaw Regep, Cristian Georges, Guy Kelm, Sebastian Popovic, Bojana Deane, Charlotte M. Nucleic Acids Res Web Server issue SAbPred is a server that makes predictions of the properties of antibodies focusing on their structures. Antibody informatics tools can help improve our understanding of immune responses to disease and aid in the design and engineering of therapeutic molecules. SAbPred is a single platform containing multiple applications which can: number and align sequences; automatically generate antibody variable fragment homology models; annotate such models with estimated accuracy alongside sequence and structural properties including potential developability issues; predict paratope residues; and predict epitope patches on protein antigens. The server is available at http://opig.stats.ox.ac.uk/webapps/sabpred. Oxford University Press 2016-07-08 2016-04-29 /pmc/articles/PMC4987913/ /pubmed/27131379 http://dx.doi.org/10.1093/nar/gkw361 Text en © The Author(s) 2016. Published by Oxford University Press on behalf of Nucleic Acids Research. http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Web Server issue Dunbar, James Krawczyk, Konrad Leem, Jinwoo Marks, Claire Nowak, Jaroslaw Regep, Cristian Georges, Guy Kelm, Sebastian Popovic, Bojana Deane, Charlotte M. SAbPred: a structure-based antibody prediction server |
title | SAbPred: a structure-based antibody prediction server |
title_full | SAbPred: a structure-based antibody prediction server |
title_fullStr | SAbPred: a structure-based antibody prediction server |
title_full_unstemmed | SAbPred: a structure-based antibody prediction server |
title_short | SAbPred: a structure-based antibody prediction server |
title_sort | sabpred: a structure-based antibody prediction server |
topic | Web Server issue |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4987913/ https://www.ncbi.nlm.nih.gov/pubmed/27131379 http://dx.doi.org/10.1093/nar/gkw361 |
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