Characterization of VHL missense mutations in sporadic clear cell renal cell carcinoma: hotspots, affected binding domains, functional impact on pVHL and therapeutic relevance

BACKGROUND: The VHL protein (pVHL) is a multiadaptor protein that interacts with more than 30 different binding partners involved in many oncogenic processes. About 70 % of clear cell renal cell carcinoma (ccRCC) have VHL mutations with varying impact on pVHL function. Loss of pVHL function leads to...

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Detalles Bibliográficos
Autores principales: Razafinjatovo, Caroline, Bihr, Svenja, Mischo, Axel, Vogl, Ursula, Schmidinger, Manuela, Moch, Holger, Schraml, Peter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4987997/
https://www.ncbi.nlm.nih.gov/pubmed/27530247
http://dx.doi.org/10.1186/s12885-016-2688-0

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