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Comparative effectiveness research for the clinician researcher: a framework for making a methodological design choice

Comparative effectiveness research compares two active forms of treatment or usual care in comparison with usual care with an additional intervention element. These types of study are commonly conducted following a placebo or no active treatment trial. Research designs with a placebo or non-active t...

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Autores principales: Williams, Cylie M., Skinner, Elizabeth H., James, Alicia M., Cook, Jill L., McPhail, Steven M., Haines, Terry P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4988047/
https://www.ncbi.nlm.nih.gov/pubmed/27530915
http://dx.doi.org/10.1186/s13063-016-1535-6
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author Williams, Cylie M.
Skinner, Elizabeth H.
James, Alicia M.
Cook, Jill L.
McPhail, Steven M.
Haines, Terry P.
author_facet Williams, Cylie M.
Skinner, Elizabeth H.
James, Alicia M.
Cook, Jill L.
McPhail, Steven M.
Haines, Terry P.
author_sort Williams, Cylie M.
collection PubMed
description Comparative effectiveness research compares two active forms of treatment or usual care in comparison with usual care with an additional intervention element. These types of study are commonly conducted following a placebo or no active treatment trial. Research designs with a placebo or non-active treatment arm can be challenging for the clinician researcher when conducted within the healthcare environment with patients attending for treatment. A framework for conducting comparative effectiveness research is needed, particularly for interventions for which there are no strong regulatory requirements that must be met prior to their introduction into usual care. We argue for a broader use of comparative effectiveness research to achieve translatable real-world clinical research. These types of research design also affect the rapid uptake of evidence-based clinical practice within the healthcare setting. This framework includes questions to guide the clinician researcher into the most appropriate trial design to measure treatment effect. These questions include consideration given to current treatment provision during usual care, known treatment effectiveness, side effects of treatments, economic impact, and the setting in which the research is being undertaken.
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spelling pubmed-49880472016-08-18 Comparative effectiveness research for the clinician researcher: a framework for making a methodological design choice Williams, Cylie M. Skinner, Elizabeth H. James, Alicia M. Cook, Jill L. McPhail, Steven M. Haines, Terry P. Trials Commentary Comparative effectiveness research compares two active forms of treatment or usual care in comparison with usual care with an additional intervention element. These types of study are commonly conducted following a placebo or no active treatment trial. Research designs with a placebo or non-active treatment arm can be challenging for the clinician researcher when conducted within the healthcare environment with patients attending for treatment. A framework for conducting comparative effectiveness research is needed, particularly for interventions for which there are no strong regulatory requirements that must be met prior to their introduction into usual care. We argue for a broader use of comparative effectiveness research to achieve translatable real-world clinical research. These types of research design also affect the rapid uptake of evidence-based clinical practice within the healthcare setting. This framework includes questions to guide the clinician researcher into the most appropriate trial design to measure treatment effect. These questions include consideration given to current treatment provision during usual care, known treatment effectiveness, side effects of treatments, economic impact, and the setting in which the research is being undertaken. BioMed Central 2016-08-17 /pmc/articles/PMC4988047/ /pubmed/27530915 http://dx.doi.org/10.1186/s13063-016-1535-6 Text en © The Author(s). 2016 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Commentary
Williams, Cylie M.
Skinner, Elizabeth H.
James, Alicia M.
Cook, Jill L.
McPhail, Steven M.
Haines, Terry P.
Comparative effectiveness research for the clinician researcher: a framework for making a methodological design choice
title Comparative effectiveness research for the clinician researcher: a framework for making a methodological design choice
title_full Comparative effectiveness research for the clinician researcher: a framework for making a methodological design choice
title_fullStr Comparative effectiveness research for the clinician researcher: a framework for making a methodological design choice
title_full_unstemmed Comparative effectiveness research for the clinician researcher: a framework for making a methodological design choice
title_short Comparative effectiveness research for the clinician researcher: a framework for making a methodological design choice
title_sort comparative effectiveness research for the clinician researcher: a framework for making a methodological design choice
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4988047/
https://www.ncbi.nlm.nih.gov/pubmed/27530915
http://dx.doi.org/10.1186/s13063-016-1535-6
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