The ACVR1 R206H mutation found in fibrodysplasia ossificans progressiva increases human induced pluripotent stem cell-derived endothelial cell formation and collagen production through BMP-mediated SMAD1/5/8 signaling

BACKGROUND: The Activin A and bone morphogenetic protein (BMP) pathways are critical regulators of the immune system and of bone formation. Inappropriate activation of these pathways, as in conditions of congenital heterotopic ossification, are thought to activate an osteogenic program in endothelia...

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Detalles Bibliográficos
Autores principales: Barruet, Emilie, Morales, Blanca M., Lwin, Wint, White, Mark P., Theodoris, Christina V., Kim, Hannah, Urrutia, Ashley, Wong, Sarah Anne, Srivastava, Deepak, Hsiao, Edward C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4988052/
https://www.ncbi.nlm.nih.gov/pubmed/27530160
http://dx.doi.org/10.1186/s13287-016-0372-6

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