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Endothelial Dysfunction in Idiopathic Sudden Sensorineural Hearing Loss: A Review

An endothelial dysfunction has been described in idiopathic sudden sensorineural hearing loss (ISSHL) patients. The purpose of our review was to: i) identify, evaluate and review recent research about cardiovascular risk factors involvement and signs of endothelial dysfunction in ISSHL; ii) implicat...

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Autores principales: Quaranta, Nicola, De Ceglie, Vincenzo, D’Elia, Alessandra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: PAGEPress Publications, Pavia, Italy 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4988098/
https://www.ncbi.nlm.nih.gov/pubmed/27588164
http://dx.doi.org/10.4081/audiores.2016.151
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author Quaranta, Nicola
De Ceglie, Vincenzo
D’Elia, Alessandra
author_facet Quaranta, Nicola
De Ceglie, Vincenzo
D’Elia, Alessandra
author_sort Quaranta, Nicola
collection PubMed
description An endothelial dysfunction has been described in idiopathic sudden sensorineural hearing loss (ISSHL) patients. The purpose of our review was to: i) identify, evaluate and review recent research about cardiovascular risk factors involvement and signs of endothelial dysfunction in ISSHL; ii) implication of these discovering in clinical practice and future research. A Medline literature search was conducted to identify any study on the involvement of endothelial dysfunction in ISSHL, published in the English language in the last decade. The following MEDLINE search terms were used: sudden sensorineural hearing loss (SSHL) and endothelial dysfunction (text words). Additional studies were identified by hand searching the references of original articles and review articles. Studies were not excluded on the basis of the qualitative or quantitative definitions of SSHL, treatment regimens, or outcome measures. Data were extracted from included papers by a reviewer. Information on the patients, investigations, methods, interventions, and outcomes were systematically analyzed. Characteristics and results of all included studies were reviewed systematically. High levels of adhesion molecules, hyperhomocysteinemia and lower folate levels, unbalanced oxidative status, a lower value of flow-mediated dilatation of brachial artery and a reduced percentage of circulating endothelial progenitor cells in patients affected by ISSHL support the hypothesis that this syndrome should be considered as a microcirculation disorder based on endothelial dysfunction and drive clinicians to implement all the traditional strategies used for preventing cardiovascular events, to also reduce the likelihood of ISSHL occurrence.
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spelling pubmed-49880982016-09-01 Endothelial Dysfunction in Idiopathic Sudden Sensorineural Hearing Loss: A Review Quaranta, Nicola De Ceglie, Vincenzo D’Elia, Alessandra Audiol Res Review An endothelial dysfunction has been described in idiopathic sudden sensorineural hearing loss (ISSHL) patients. The purpose of our review was to: i) identify, evaluate and review recent research about cardiovascular risk factors involvement and signs of endothelial dysfunction in ISSHL; ii) implication of these discovering in clinical practice and future research. A Medline literature search was conducted to identify any study on the involvement of endothelial dysfunction in ISSHL, published in the English language in the last decade. The following MEDLINE search terms were used: sudden sensorineural hearing loss (SSHL) and endothelial dysfunction (text words). Additional studies were identified by hand searching the references of original articles and review articles. Studies were not excluded on the basis of the qualitative or quantitative definitions of SSHL, treatment regimens, or outcome measures. Data were extracted from included papers by a reviewer. Information on the patients, investigations, methods, interventions, and outcomes were systematically analyzed. Characteristics and results of all included studies were reviewed systematically. High levels of adhesion molecules, hyperhomocysteinemia and lower folate levels, unbalanced oxidative status, a lower value of flow-mediated dilatation of brachial artery and a reduced percentage of circulating endothelial progenitor cells in patients affected by ISSHL support the hypothesis that this syndrome should be considered as a microcirculation disorder based on endothelial dysfunction and drive clinicians to implement all the traditional strategies used for preventing cardiovascular events, to also reduce the likelihood of ISSHL occurrence. PAGEPress Publications, Pavia, Italy 2016-07-27 /pmc/articles/PMC4988098/ /pubmed/27588164 http://dx.doi.org/10.4081/audiores.2016.151 Text en ©Copyright N. Quaranta et al. http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review
Quaranta, Nicola
De Ceglie, Vincenzo
D’Elia, Alessandra
Endothelial Dysfunction in Idiopathic Sudden Sensorineural Hearing Loss: A Review
title Endothelial Dysfunction in Idiopathic Sudden Sensorineural Hearing Loss: A Review
title_full Endothelial Dysfunction in Idiopathic Sudden Sensorineural Hearing Loss: A Review
title_fullStr Endothelial Dysfunction in Idiopathic Sudden Sensorineural Hearing Loss: A Review
title_full_unstemmed Endothelial Dysfunction in Idiopathic Sudden Sensorineural Hearing Loss: A Review
title_short Endothelial Dysfunction in Idiopathic Sudden Sensorineural Hearing Loss: A Review
title_sort endothelial dysfunction in idiopathic sudden sensorineural hearing loss: a review
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4988098/
https://www.ncbi.nlm.nih.gov/pubmed/27588164
http://dx.doi.org/10.4081/audiores.2016.151
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