A comparison of foamy and lentiviral vector genotoxicity in SCID-repopulating cells shows foamy vectors are less prone to clonal dominance

Hematopoietic stem cell (HSC) gene therapy using retroviral vectors has immense potential, but vector-mediated genotoxicity limits use in the clinic. Lentiviral vectors are less genotoxic than gammaretroviral vectors and have become the vector of choice in clinical trials. Foamy retroviral vectors h...

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Detalles Bibliográficos
Autores principales: Everson, Elizabeth M, Olzsko, Miles E, Leap, David J, Hocum, Jonah D, Trobridge, Grant D
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4988344/
https://www.ncbi.nlm.nih.gov/pubmed/27579335
http://dx.doi.org/10.1038/mtm.2016.48

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