Rosmarinus officinalis L. increases Caenorhabditis elegans stress resistance and longevity in a DAF-16, HSF-1 and SKN-1-dependent manner

Improving overall health and quality of life, preventing diseases and increasing life expectancy are key concerns in the field of public health. The search for antioxidants that can inhibit oxidative damage in cells has received a lot of attention. Rosmarinus officinalis L. represents an exceptional...

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Autores principales: Zamberlan, D.C., Amaral, G.P., Arantes, L.P., Machado, M.L., Mizdal, C.R., Campos, M.M.A., Soares, F.A.A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Associação Brasileira de Divulgação Científica 2016
Materias:
Biomedical Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4988476/
https://www.ncbi.nlm.nih.gov/pubmed/27533765
http://dx.doi.org/10.1590/1414-431X20165235
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author Zamberlan, D.C.
Amaral, G.P.
Arantes, L.P.
Machado, M.L.
Mizdal, C.R.
Campos, M.M.A.
Soares, F.A.A.
author_facet Zamberlan, D.C.
Amaral, G.P.
Arantes, L.P.
Machado, M.L.
Mizdal, C.R.
Campos, M.M.A.
Soares, F.A.A.
author_sort Zamberlan, D.C.
collection PubMed
description Improving overall health and quality of life, preventing diseases and increasing life expectancy are key concerns in the field of public health. The search for antioxidants that can inhibit oxidative damage in cells has received a lot of attention. Rosmarinus officinalis L. represents an exceptionally rich source of bioactive compounds with pharmacological properties. In the present study, we explored the effects of the ethanolic extract of R. officinalis (eeRo) on stress resistance and longevity using the non-parasitic nematode Caenorhabditis elegans as a model. We report for the first time that eeRo increased resistance against oxidative and thermal stress and extended C. elegans longevity in an insulin/IGF signaling pathway-dependent manner. These data emphasize the eeRo beneficial effects on C. elegans under stress.
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spelling pubmed-49884762016-08-31 Rosmarinus officinalis L. increases Caenorhabditis elegans stress resistance and longevity in a DAF-16, HSF-1 and SKN-1-dependent manner Zamberlan, D.C. Amaral, G.P. Arantes, L.P. Machado, M.L. Mizdal, C.R. Campos, M.M.A. Soares, F.A.A. Braz J Med Biol Res Biomedical Sciences Improving overall health and quality of life, preventing diseases and increasing life expectancy are key concerns in the field of public health. The search for antioxidants that can inhibit oxidative damage in cells has received a lot of attention. Rosmarinus officinalis L. represents an exceptionally rich source of bioactive compounds with pharmacological properties. In the present study, we explored the effects of the ethanolic extract of R. officinalis (eeRo) on stress resistance and longevity using the non-parasitic nematode Caenorhabditis elegans as a model. We report for the first time that eeRo increased resistance against oxidative and thermal stress and extended C. elegans longevity in an insulin/IGF signaling pathway-dependent manner. These data emphasize the eeRo beneficial effects on C. elegans under stress. Associação Brasileira de Divulgação Científica 2016-08-01 /pmc/articles/PMC4988476/ /pubmed/27533765 http://dx.doi.org/10.1590/1414-431X20165235 Text en http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License
spellingShingle Biomedical Sciences
Zamberlan, D.C.
Amaral, G.P.
Arantes, L.P.
Machado, M.L.
Mizdal, C.R.
Campos, M.M.A.
Soares, F.A.A.
Rosmarinus officinalis L. increases Caenorhabditis elegans stress resistance and longevity in a DAF-16, HSF-1 and SKN-1-dependent manner
title Rosmarinus officinalis L. increases Caenorhabditis elegans stress resistance and longevity in a DAF-16, HSF-1 and SKN-1-dependent manner
title_full Rosmarinus officinalis L. increases Caenorhabditis elegans stress resistance and longevity in a DAF-16, HSF-1 and SKN-1-dependent manner
title_fullStr Rosmarinus officinalis L. increases Caenorhabditis elegans stress resistance and longevity in a DAF-16, HSF-1 and SKN-1-dependent manner
title_full_unstemmed Rosmarinus officinalis L. increases Caenorhabditis elegans stress resistance and longevity in a DAF-16, HSF-1 and SKN-1-dependent manner
title_short Rosmarinus officinalis L. increases Caenorhabditis elegans stress resistance and longevity in a DAF-16, HSF-1 and SKN-1-dependent manner
title_sort rosmarinus officinalis l. increases caenorhabditis elegans stress resistance and longevity in a daf-16, hsf-1 and skn-1-dependent manner
topic Biomedical Sciences
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4988476/
https://www.ncbi.nlm.nih.gov/pubmed/27533765
http://dx.doi.org/10.1590/1414-431X20165235
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