Cargando…

Association of exercise training and angiotensin-converting enzyme 2 activator improves baroreflex sensitivity of spontaneously hypertensive rats

The present study sought to determine cardiovascular effects of aerobic training associated with diminazene aceturate (DIZE), an activator of the angiotensin converting enzyme 2, in spontaneously hypertensive rats (SHRs). Male SHRs (280–350 g) were either subjected to exercise training or not (seden...

Descripción completa

Detalles Bibliográficos
Autores principales: Lopes, P.R., Moreira, M.C.S., Marques, S.M., Pinto, I.S.J., Macedo, L.M., Silva, C.C., Freiria-Oliveira, A.H., Rebelo, A.C.S., Reis, A.A.S., Rosa, D.A., Ferreira-Neto, M.L., Castro, C.H., Pedrino, G.R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Associação Brasileira de Divulgação Científica 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4988479/
https://www.ncbi.nlm.nih.gov/pubmed/27533767
http://dx.doi.org/10.1590/1414-431X20165349
_version_ 1782448437069873152
author Lopes, P.R.
Moreira, M.C.S.
Marques, S.M.
Pinto, I.S.J.
Macedo, L.M.
Silva, C.C.
Freiria-Oliveira, A.H.
Rebelo, A.C.S.
Reis, A.A.S.
Rosa, D.A.
Ferreira-Neto, M.L.
Castro, C.H.
Pedrino, G.R.
author_facet Lopes, P.R.
Moreira, M.C.S.
Marques, S.M.
Pinto, I.S.J.
Macedo, L.M.
Silva, C.C.
Freiria-Oliveira, A.H.
Rebelo, A.C.S.
Reis, A.A.S.
Rosa, D.A.
Ferreira-Neto, M.L.
Castro, C.H.
Pedrino, G.R.
author_sort Lopes, P.R.
collection PubMed
description The present study sought to determine cardiovascular effects of aerobic training associated with diminazene aceturate (DIZE), an activator of the angiotensin converting enzyme 2, in spontaneously hypertensive rats (SHRs). Male SHRs (280–350 g) were either subjected to exercise training or not (sedentary group). The trained group was subjected to 8 weeks of aerobic training on a treadmill (five times a week, lasting 60 min at an intensity of 50–60% of maximum aerobic speed). In the last 15 days of the experimental protocol, these groups were redistributed into four groups: i) sedentary SHRs with daily treatment of 1 mg/kg DIZE (S+D1); ii) trained SHRs with daily treatment of 1 mg/kg DIZE (T+D1); iii) sedentary SHRs with daily treatment of vehicle (S+V); and iv) trained SHRs with daily treatment of vehicle (T+V). After treatment, SHRs were anesthetized and subjected to artery and femoral vein cannulation prior to the implantation of ECG electrode. After 24 h, mean arterial pressure (MAP) and heart rate (HR) were recorded; the baroreflex sensitivity and the effect of double autonomic blockade (DAB) were evaluated in non-anesthetized SHRs. DIZE treatment improved baroreflex sensitivity in the T+D1 group as compared with the T+V and S+D1 groups. The intrinsic heart rate (IHR) and MAP were reduced in T+D1 group as compared with T+V and S+D1 groups. Hence, we conclude that the association of exercise training with DIZE treatment improved baroreflex function and cardiovascular regulation.
format Online
Article
Text
id pubmed-4988479
institution National Center for Biotechnology Information
language English
publishDate 2016
publisher Associação Brasileira de Divulgação Científica
record_format MEDLINE/PubMed
spelling pubmed-49884792016-08-31 Association of exercise training and angiotensin-converting enzyme 2 activator improves baroreflex sensitivity of spontaneously hypertensive rats Lopes, P.R. Moreira, M.C.S. Marques, S.M. Pinto, I.S.J. Macedo, L.M. Silva, C.C. Freiria-Oliveira, A.H. Rebelo, A.C.S. Reis, A.A.S. Rosa, D.A. Ferreira-Neto, M.L. Castro, C.H. Pedrino, G.R. Braz J Med Biol Res Biomedical Sciences The present study sought to determine cardiovascular effects of aerobic training associated with diminazene aceturate (DIZE), an activator of the angiotensin converting enzyme 2, in spontaneously hypertensive rats (SHRs). Male SHRs (280–350 g) were either subjected to exercise training or not (sedentary group). The trained group was subjected to 8 weeks of aerobic training on a treadmill (five times a week, lasting 60 min at an intensity of 50–60% of maximum aerobic speed). In the last 15 days of the experimental protocol, these groups were redistributed into four groups: i) sedentary SHRs with daily treatment of 1 mg/kg DIZE (S+D1); ii) trained SHRs with daily treatment of 1 mg/kg DIZE (T+D1); iii) sedentary SHRs with daily treatment of vehicle (S+V); and iv) trained SHRs with daily treatment of vehicle (T+V). After treatment, SHRs were anesthetized and subjected to artery and femoral vein cannulation prior to the implantation of ECG electrode. After 24 h, mean arterial pressure (MAP) and heart rate (HR) were recorded; the baroreflex sensitivity and the effect of double autonomic blockade (DAB) were evaluated in non-anesthetized SHRs. DIZE treatment improved baroreflex sensitivity in the T+D1 group as compared with the T+V and S+D1 groups. The intrinsic heart rate (IHR) and MAP were reduced in T+D1 group as compared with T+V and S+D1 groups. Hence, we conclude that the association of exercise training with DIZE treatment improved baroreflex function and cardiovascular regulation. Associação Brasileira de Divulgação Científica 2016-08-01 /pmc/articles/PMC4988479/ /pubmed/27533767 http://dx.doi.org/10.1590/1414-431X20165349 Text en http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License
spellingShingle Biomedical Sciences
Lopes, P.R.
Moreira, M.C.S.
Marques, S.M.
Pinto, I.S.J.
Macedo, L.M.
Silva, C.C.
Freiria-Oliveira, A.H.
Rebelo, A.C.S.
Reis, A.A.S.
Rosa, D.A.
Ferreira-Neto, M.L.
Castro, C.H.
Pedrino, G.R.
Association of exercise training and angiotensin-converting enzyme 2 activator improves baroreflex sensitivity of spontaneously hypertensive rats
title Association of exercise training and angiotensin-converting enzyme 2 activator improves baroreflex sensitivity of spontaneously hypertensive rats
title_full Association of exercise training and angiotensin-converting enzyme 2 activator improves baroreflex sensitivity of spontaneously hypertensive rats
title_fullStr Association of exercise training and angiotensin-converting enzyme 2 activator improves baroreflex sensitivity of spontaneously hypertensive rats
title_full_unstemmed Association of exercise training and angiotensin-converting enzyme 2 activator improves baroreflex sensitivity of spontaneously hypertensive rats
title_short Association of exercise training and angiotensin-converting enzyme 2 activator improves baroreflex sensitivity of spontaneously hypertensive rats
title_sort association of exercise training and angiotensin-converting enzyme 2 activator improves baroreflex sensitivity of spontaneously hypertensive rats
topic Biomedical Sciences
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4988479/
https://www.ncbi.nlm.nih.gov/pubmed/27533767
http://dx.doi.org/10.1590/1414-431X20165349
work_keys_str_mv AT lopespr associationofexercisetrainingandangiotensinconvertingenzyme2activatorimprovesbaroreflexsensitivityofspontaneouslyhypertensiverats
AT moreiramcs associationofexercisetrainingandangiotensinconvertingenzyme2activatorimprovesbaroreflexsensitivityofspontaneouslyhypertensiverats
AT marquessm associationofexercisetrainingandangiotensinconvertingenzyme2activatorimprovesbaroreflexsensitivityofspontaneouslyhypertensiverats
AT pintoisj associationofexercisetrainingandangiotensinconvertingenzyme2activatorimprovesbaroreflexsensitivityofspontaneouslyhypertensiverats
AT macedolm associationofexercisetrainingandangiotensinconvertingenzyme2activatorimprovesbaroreflexsensitivityofspontaneouslyhypertensiverats
AT silvacc associationofexercisetrainingandangiotensinconvertingenzyme2activatorimprovesbaroreflexsensitivityofspontaneouslyhypertensiverats
AT freiriaoliveiraah associationofexercisetrainingandangiotensinconvertingenzyme2activatorimprovesbaroreflexsensitivityofspontaneouslyhypertensiverats
AT rebeloacs associationofexercisetrainingandangiotensinconvertingenzyme2activatorimprovesbaroreflexsensitivityofspontaneouslyhypertensiverats
AT reisaas associationofexercisetrainingandangiotensinconvertingenzyme2activatorimprovesbaroreflexsensitivityofspontaneouslyhypertensiverats
AT rosada associationofexercisetrainingandangiotensinconvertingenzyme2activatorimprovesbaroreflexsensitivityofspontaneouslyhypertensiverats
AT ferreiranetoml associationofexercisetrainingandangiotensinconvertingenzyme2activatorimprovesbaroreflexsensitivityofspontaneouslyhypertensiverats
AT castroch associationofexercisetrainingandangiotensinconvertingenzyme2activatorimprovesbaroreflexsensitivityofspontaneouslyhypertensiverats
AT pedrinogr associationofexercisetrainingandangiotensinconvertingenzyme2activatorimprovesbaroreflexsensitivityofspontaneouslyhypertensiverats