Cargando…

A Single Mass Forming Colonic Primary Mantle Cell Lymphoma

Mantle cell lymphoma (MCL) is a subtype of non-Hodgkin's lymphoma (NHL) comprising around 7% of adult NHL. It is characterized by a chromosomal translocation t(11:14) and overexpression of Cyclin D1. The incidence of secondary gastrointestinal tract involvement in MCL ranges from 10 to 28% in v...

Descripción completa

Detalles Bibliográficos
Autores principales: Daniel, Fady, Assi, Hazem I., Karaoui, Walid, El Cheikh, Jean, Bannoura, Sami, Nassif, Samer
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4989071/
https://www.ncbi.nlm.nih.gov/pubmed/27579189
http://dx.doi.org/10.1155/2016/2561507
_version_ 1782448508502016000
author Daniel, Fady
Assi, Hazem I.
Karaoui, Walid
El Cheikh, Jean
Bannoura, Sami
Nassif, Samer
author_facet Daniel, Fady
Assi, Hazem I.
Karaoui, Walid
El Cheikh, Jean
Bannoura, Sami
Nassif, Samer
author_sort Daniel, Fady
collection PubMed
description Mantle cell lymphoma (MCL) is a subtype of non-Hodgkin's lymphoma (NHL) comprising around 7% of adult NHL. It is characterized by a chromosomal translocation t(11:14) and overexpression of Cyclin D1. The incidence of secondary gastrointestinal tract involvement in MCL ranges from 10 to 28% in various series. However primary gastrointestinal MCL is very rare, accounting for only 1 to 4% of primary gastrointestinal lymphomas. The most common endoscopic feature of primary intestinal MCL is multiple lymphomatous polyposis. In rare cases it presents as protruded lesions or superficial lesions. Single colonic mass presentation is an extremely infrequent presentation. MCL has an aggressive course with quick progression, and most cases are discovered in the advanced stages. Colonic biopsies with histologic examination and specific immunohistochemical staining are the gold standard for a proper diagnosis. We report a case of a single mass forming mantle cell lymphoma of the ascending colon in a 57-year-old female patient with unusual colonoscopic and radiologic features and describe the therapy the patient received, thereby adding to the spectrum of clinical presentations of this aggressive lymphoproliferative disorder.
format Online
Article
Text
id pubmed-4989071
institution National Center for Biotechnology Information
language English
publishDate 2016
publisher Hindawi Publishing Corporation
record_format MEDLINE/PubMed
spelling pubmed-49890712016-08-30 A Single Mass Forming Colonic Primary Mantle Cell Lymphoma Daniel, Fady Assi, Hazem I. Karaoui, Walid El Cheikh, Jean Bannoura, Sami Nassif, Samer Case Rep Gastrointest Med Case Report Mantle cell lymphoma (MCL) is a subtype of non-Hodgkin's lymphoma (NHL) comprising around 7% of adult NHL. It is characterized by a chromosomal translocation t(11:14) and overexpression of Cyclin D1. The incidence of secondary gastrointestinal tract involvement in MCL ranges from 10 to 28% in various series. However primary gastrointestinal MCL is very rare, accounting for only 1 to 4% of primary gastrointestinal lymphomas. The most common endoscopic feature of primary intestinal MCL is multiple lymphomatous polyposis. In rare cases it presents as protruded lesions or superficial lesions. Single colonic mass presentation is an extremely infrequent presentation. MCL has an aggressive course with quick progression, and most cases are discovered in the advanced stages. Colonic biopsies with histologic examination and specific immunohistochemical staining are the gold standard for a proper diagnosis. We report a case of a single mass forming mantle cell lymphoma of the ascending colon in a 57-year-old female patient with unusual colonoscopic and radiologic features and describe the therapy the patient received, thereby adding to the spectrum of clinical presentations of this aggressive lymphoproliferative disorder. Hindawi Publishing Corporation 2016 2016-08-04 /pmc/articles/PMC4989071/ /pubmed/27579189 http://dx.doi.org/10.1155/2016/2561507 Text en Copyright © 2016 Fady Daniel et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Daniel, Fady
Assi, Hazem I.
Karaoui, Walid
El Cheikh, Jean
Bannoura, Sami
Nassif, Samer
A Single Mass Forming Colonic Primary Mantle Cell Lymphoma
title A Single Mass Forming Colonic Primary Mantle Cell Lymphoma
title_full A Single Mass Forming Colonic Primary Mantle Cell Lymphoma
title_fullStr A Single Mass Forming Colonic Primary Mantle Cell Lymphoma
title_full_unstemmed A Single Mass Forming Colonic Primary Mantle Cell Lymphoma
title_short A Single Mass Forming Colonic Primary Mantle Cell Lymphoma
title_sort single mass forming colonic primary mantle cell lymphoma
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4989071/
https://www.ncbi.nlm.nih.gov/pubmed/27579189
http://dx.doi.org/10.1155/2016/2561507
work_keys_str_mv AT danielfady asinglemassformingcolonicprimarymantlecelllymphoma
AT assihazemi asinglemassformingcolonicprimarymantlecelllymphoma
AT karaouiwalid asinglemassformingcolonicprimarymantlecelllymphoma
AT elcheikhjean asinglemassformingcolonicprimarymantlecelllymphoma
AT bannourasami asinglemassformingcolonicprimarymantlecelllymphoma
AT nassifsamer asinglemassformingcolonicprimarymantlecelllymphoma
AT danielfady singlemassformingcolonicprimarymantlecelllymphoma
AT assihazemi singlemassformingcolonicprimarymantlecelllymphoma
AT karaouiwalid singlemassformingcolonicprimarymantlecelllymphoma
AT elcheikhjean singlemassformingcolonicprimarymantlecelllymphoma
AT bannourasami singlemassformingcolonicprimarymantlecelllymphoma
AT nassifsamer singlemassformingcolonicprimarymantlecelllymphoma