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A Single Mass Forming Colonic Primary Mantle Cell Lymphoma
Mantle cell lymphoma (MCL) is a subtype of non-Hodgkin's lymphoma (NHL) comprising around 7% of adult NHL. It is characterized by a chromosomal translocation t(11:14) and overexpression of Cyclin D1. The incidence of secondary gastrointestinal tract involvement in MCL ranges from 10 to 28% in v...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4989071/ https://www.ncbi.nlm.nih.gov/pubmed/27579189 http://dx.doi.org/10.1155/2016/2561507 |
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author | Daniel, Fady Assi, Hazem I. Karaoui, Walid El Cheikh, Jean Bannoura, Sami Nassif, Samer |
author_facet | Daniel, Fady Assi, Hazem I. Karaoui, Walid El Cheikh, Jean Bannoura, Sami Nassif, Samer |
author_sort | Daniel, Fady |
collection | PubMed |
description | Mantle cell lymphoma (MCL) is a subtype of non-Hodgkin's lymphoma (NHL) comprising around 7% of adult NHL. It is characterized by a chromosomal translocation t(11:14) and overexpression of Cyclin D1. The incidence of secondary gastrointestinal tract involvement in MCL ranges from 10 to 28% in various series. However primary gastrointestinal MCL is very rare, accounting for only 1 to 4% of primary gastrointestinal lymphomas. The most common endoscopic feature of primary intestinal MCL is multiple lymphomatous polyposis. In rare cases it presents as protruded lesions or superficial lesions. Single colonic mass presentation is an extremely infrequent presentation. MCL has an aggressive course with quick progression, and most cases are discovered in the advanced stages. Colonic biopsies with histologic examination and specific immunohistochemical staining are the gold standard for a proper diagnosis. We report a case of a single mass forming mantle cell lymphoma of the ascending colon in a 57-year-old female patient with unusual colonoscopic and radiologic features and describe the therapy the patient received, thereby adding to the spectrum of clinical presentations of this aggressive lymphoproliferative disorder. |
format | Online Article Text |
id | pubmed-4989071 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-49890712016-08-30 A Single Mass Forming Colonic Primary Mantle Cell Lymphoma Daniel, Fady Assi, Hazem I. Karaoui, Walid El Cheikh, Jean Bannoura, Sami Nassif, Samer Case Rep Gastrointest Med Case Report Mantle cell lymphoma (MCL) is a subtype of non-Hodgkin's lymphoma (NHL) comprising around 7% of adult NHL. It is characterized by a chromosomal translocation t(11:14) and overexpression of Cyclin D1. The incidence of secondary gastrointestinal tract involvement in MCL ranges from 10 to 28% in various series. However primary gastrointestinal MCL is very rare, accounting for only 1 to 4% of primary gastrointestinal lymphomas. The most common endoscopic feature of primary intestinal MCL is multiple lymphomatous polyposis. In rare cases it presents as protruded lesions or superficial lesions. Single colonic mass presentation is an extremely infrequent presentation. MCL has an aggressive course with quick progression, and most cases are discovered in the advanced stages. Colonic biopsies with histologic examination and specific immunohistochemical staining are the gold standard for a proper diagnosis. We report a case of a single mass forming mantle cell lymphoma of the ascending colon in a 57-year-old female patient with unusual colonoscopic and radiologic features and describe the therapy the patient received, thereby adding to the spectrum of clinical presentations of this aggressive lymphoproliferative disorder. Hindawi Publishing Corporation 2016 2016-08-04 /pmc/articles/PMC4989071/ /pubmed/27579189 http://dx.doi.org/10.1155/2016/2561507 Text en Copyright © 2016 Fady Daniel et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Case Report Daniel, Fady Assi, Hazem I. Karaoui, Walid El Cheikh, Jean Bannoura, Sami Nassif, Samer A Single Mass Forming Colonic Primary Mantle Cell Lymphoma |
title | A Single Mass Forming Colonic Primary Mantle Cell Lymphoma |
title_full | A Single Mass Forming Colonic Primary Mantle Cell Lymphoma |
title_fullStr | A Single Mass Forming Colonic Primary Mantle Cell Lymphoma |
title_full_unstemmed | A Single Mass Forming Colonic Primary Mantle Cell Lymphoma |
title_short | A Single Mass Forming Colonic Primary Mantle Cell Lymphoma |
title_sort | single mass forming colonic primary mantle cell lymphoma |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4989071/ https://www.ncbi.nlm.nih.gov/pubmed/27579189 http://dx.doi.org/10.1155/2016/2561507 |
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