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Metabolism and Ovarian Function in PCOS Women: A Therapeutic Approach with Inositols
Polycystic ovary syndrome (PCOS) is characterized by chronical anovulation and hyperandrogenism which may be present in a different degree of severity. Insulin-resistance and hyperinsulinemia are the main physiopathological basis of this syndrome and the failure of inositol-mediated signaling may co...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4989075/ https://www.ncbi.nlm.nih.gov/pubmed/27579037 http://dx.doi.org/10.1155/2016/6306410 |
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author | Laganà, Antonio Simone Rossetti, Paola Buscema, Massimo La Vignera, Sandro Condorelli, Rosita Angela Gullo, Giuseppe Granese, Roberta Triolo, Onofrio |
author_facet | Laganà, Antonio Simone Rossetti, Paola Buscema, Massimo La Vignera, Sandro Condorelli, Rosita Angela Gullo, Giuseppe Granese, Roberta Triolo, Onofrio |
author_sort | Laganà, Antonio Simone |
collection | PubMed |
description | Polycystic ovary syndrome (PCOS) is characterized by chronical anovulation and hyperandrogenism which may be present in a different degree of severity. Insulin-resistance and hyperinsulinemia are the main physiopathological basis of this syndrome and the failure of inositol-mediated signaling may concur to them. Myo (MI) and D-chiro-inositol (DCI), the most studied inositol isoforms, are classified as insulin sensitizers. In form of glycans, DCI-phosphoglycan and MI-phosphoglycan control key enzymes were involved in glucose and lipid metabolism. In form of phosphoinositides, they play an important role as second messengers in several cellular biological functions. Considering the key role played by insulin-resistance and androgen excess in PCOS patients, the insulin-sensitizing effects of both MI and DCI were tested in order to ameliorate symptoms and signs of this syndrome, including the possibility to restore patients' fertility. Accumulating evidence suggests that both isoforms of inositol are effective in improving ovarian function and metabolism in patients with PCOS, although MI showed the most marked effect on the metabolic profile, whereas DCI reduced hyperandrogenism better. The purpose of this review is to provide an update on inositol signaling and correlate data on biological functions of these multifaceted molecules, in view of a rational use for the therapy in women with PCOS. |
format | Online Article Text |
id | pubmed-4989075 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-49890752016-08-30 Metabolism and Ovarian Function in PCOS Women: A Therapeutic Approach with Inositols Laganà, Antonio Simone Rossetti, Paola Buscema, Massimo La Vignera, Sandro Condorelli, Rosita Angela Gullo, Giuseppe Granese, Roberta Triolo, Onofrio Int J Endocrinol Review Article Polycystic ovary syndrome (PCOS) is characterized by chronical anovulation and hyperandrogenism which may be present in a different degree of severity. Insulin-resistance and hyperinsulinemia are the main physiopathological basis of this syndrome and the failure of inositol-mediated signaling may concur to them. Myo (MI) and D-chiro-inositol (DCI), the most studied inositol isoforms, are classified as insulin sensitizers. In form of glycans, DCI-phosphoglycan and MI-phosphoglycan control key enzymes were involved in glucose and lipid metabolism. In form of phosphoinositides, they play an important role as second messengers in several cellular biological functions. Considering the key role played by insulin-resistance and androgen excess in PCOS patients, the insulin-sensitizing effects of both MI and DCI were tested in order to ameliorate symptoms and signs of this syndrome, including the possibility to restore patients' fertility. Accumulating evidence suggests that both isoforms of inositol are effective in improving ovarian function and metabolism in patients with PCOS, although MI showed the most marked effect on the metabolic profile, whereas DCI reduced hyperandrogenism better. The purpose of this review is to provide an update on inositol signaling and correlate data on biological functions of these multifaceted molecules, in view of a rational use for the therapy in women with PCOS. Hindawi Publishing Corporation 2016 2016-08-04 /pmc/articles/PMC4989075/ /pubmed/27579037 http://dx.doi.org/10.1155/2016/6306410 Text en Copyright © 2016 Antonio Simone Laganà et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Laganà, Antonio Simone Rossetti, Paola Buscema, Massimo La Vignera, Sandro Condorelli, Rosita Angela Gullo, Giuseppe Granese, Roberta Triolo, Onofrio Metabolism and Ovarian Function in PCOS Women: A Therapeutic Approach with Inositols |
title | Metabolism and Ovarian Function in PCOS Women: A Therapeutic Approach with Inositols |
title_full | Metabolism and Ovarian Function in PCOS Women: A Therapeutic Approach with Inositols |
title_fullStr | Metabolism and Ovarian Function in PCOS Women: A Therapeutic Approach with Inositols |
title_full_unstemmed | Metabolism and Ovarian Function in PCOS Women: A Therapeutic Approach with Inositols |
title_short | Metabolism and Ovarian Function in PCOS Women: A Therapeutic Approach with Inositols |
title_sort | metabolism and ovarian function in pcos women: a therapeutic approach with inositols |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4989075/ https://www.ncbi.nlm.nih.gov/pubmed/27579037 http://dx.doi.org/10.1155/2016/6306410 |
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