Coevolution of URAT1 and Uricase during Primate Evolution: Implications for Serum Urate Homeostasis and Gout

Uric acid is the highly insoluble end-product of purine metabolism in humans. Serum levels exceeding the solubility threshold can trigger formation of urate crystals resulting in gouty arthritis. Uric acid is primarily excreted through the kidneys with 90% reabsorbed back into the bloodstream throug...

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Detalles Bibliográficos
Autores principales: Tan, Philip K., Farrar, Jennifer E., Gaucher, Eric A., Miner, Jeffrey N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2016
Materias:
Fast Track
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4989112/
https://www.ncbi.nlm.nih.gov/pubmed/27352852
http://dx.doi.org/10.1093/molbev/msw116

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4989112/
https://www.ncbi.nlm.nih.gov/pubmed/27352852
http://dx.doi.org/10.1093/molbev/msw116

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