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The Bama miniature swine is susceptible to experimental HEV infection
The hepatitis E virus (HEV) is one of the main causes of enterically transmitted hepatitis worldwide. Although the mortality rates associated with HEV are generally low, they can be up to 28% in HEV-infected pregnant women, and the elderly are more susceptible. The reasons for this selective severit...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4989227/ https://www.ncbi.nlm.nih.gov/pubmed/27534702 http://dx.doi.org/10.1038/srep31813 |
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author | Tang, Zi-Min Wang, Si-Ling Ying, Dong Wen, Gui-Ping Cai, Wei Zhang, Ke Ji, Wen-Fang Yang, Ming Zheng, Zi-Zheng Xia, Ning-Shao |
author_facet | Tang, Zi-Min Wang, Si-Ling Ying, Dong Wen, Gui-Ping Cai, Wei Zhang, Ke Ji, Wen-Fang Yang, Ming Zheng, Zi-Zheng Xia, Ning-Shao |
author_sort | Tang, Zi-Min |
collection | PubMed |
description | The hepatitis E virus (HEV) is one of the main causes of enterically transmitted hepatitis worldwide. Although the mortality rates associated with HEV are generally low, they can be up to 28% in HEV-infected pregnant women, and the elderly are more susceptible. The reasons for this selective severity are unclear, partially because there is no suitable, easy-to-use model in which to study HEV infection. Non-human primates and standard swine have been identified as being sensitive to infection with HEV and have been used for HEV infection studies. However, studies in these animals have been limited by high housing costs and the difficulty of manipulating these animals. In the current study, we established a model of HEV infection using Bama miniature swine. The model is easy to use and is sensitive to infections with HEV genotypes 3 and 4, which are classified as zoonotic HEVs. In this model, infection of Bama miniature swine with HEV genotypes 3 and 4 caused the typical features. All Bama miniature swine that were infected with HEV genotypes 3 and 4 exhibited significant HEV viremia, shedding, anti-HEV antibody responses and partial liver inflammation. Bama miniature swine may serve as an alternative to standard swine models for the study of zoonotic HEV infection and HEV genotype specificity research. |
format | Online Article Text |
id | pubmed-4989227 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Nature Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-49892272016-08-30 The Bama miniature swine is susceptible to experimental HEV infection Tang, Zi-Min Wang, Si-Ling Ying, Dong Wen, Gui-Ping Cai, Wei Zhang, Ke Ji, Wen-Fang Yang, Ming Zheng, Zi-Zheng Xia, Ning-Shao Sci Rep Article The hepatitis E virus (HEV) is one of the main causes of enterically transmitted hepatitis worldwide. Although the mortality rates associated with HEV are generally low, they can be up to 28% in HEV-infected pregnant women, and the elderly are more susceptible. The reasons for this selective severity are unclear, partially because there is no suitable, easy-to-use model in which to study HEV infection. Non-human primates and standard swine have been identified as being sensitive to infection with HEV and have been used for HEV infection studies. However, studies in these animals have been limited by high housing costs and the difficulty of manipulating these animals. In the current study, we established a model of HEV infection using Bama miniature swine. The model is easy to use and is sensitive to infections with HEV genotypes 3 and 4, which are classified as zoonotic HEVs. In this model, infection of Bama miniature swine with HEV genotypes 3 and 4 caused the typical features. All Bama miniature swine that were infected with HEV genotypes 3 and 4 exhibited significant HEV viremia, shedding, anti-HEV antibody responses and partial liver inflammation. Bama miniature swine may serve as an alternative to standard swine models for the study of zoonotic HEV infection and HEV genotype specificity research. Nature Publishing Group 2016-08-18 /pmc/articles/PMC4989227/ /pubmed/27534702 http://dx.doi.org/10.1038/srep31813 Text en Copyright © 2016, The Author(s) http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ |
spellingShingle | Article Tang, Zi-Min Wang, Si-Ling Ying, Dong Wen, Gui-Ping Cai, Wei Zhang, Ke Ji, Wen-Fang Yang, Ming Zheng, Zi-Zheng Xia, Ning-Shao The Bama miniature swine is susceptible to experimental HEV infection |
title | The Bama miniature swine is susceptible to experimental HEV infection |
title_full | The Bama miniature swine is susceptible to experimental HEV infection |
title_fullStr | The Bama miniature swine is susceptible to experimental HEV infection |
title_full_unstemmed | The Bama miniature swine is susceptible to experimental HEV infection |
title_short | The Bama miniature swine is susceptible to experimental HEV infection |
title_sort | bama miniature swine is susceptible to experimental hev infection |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4989227/ https://www.ncbi.nlm.nih.gov/pubmed/27534702 http://dx.doi.org/10.1038/srep31813 |
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