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The Bama miniature swine is susceptible to experimental HEV infection

The hepatitis E virus (HEV) is one of the main causes of enterically transmitted hepatitis worldwide. Although the mortality rates associated with HEV are generally low, they can be up to 28% in HEV-infected pregnant women, and the elderly are more susceptible. The reasons for this selective severit...

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Autores principales: Tang, Zi-Min, Wang, Si-Ling, Ying, Dong, Wen, Gui-Ping, Cai, Wei, Zhang, Ke, Ji, Wen-Fang, Yang, Ming, Zheng, Zi-Zheng, Xia, Ning-Shao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4989227/
https://www.ncbi.nlm.nih.gov/pubmed/27534702
http://dx.doi.org/10.1038/srep31813
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author Tang, Zi-Min
Wang, Si-Ling
Ying, Dong
Wen, Gui-Ping
Cai, Wei
Zhang, Ke
Ji, Wen-Fang
Yang, Ming
Zheng, Zi-Zheng
Xia, Ning-Shao
author_facet Tang, Zi-Min
Wang, Si-Ling
Ying, Dong
Wen, Gui-Ping
Cai, Wei
Zhang, Ke
Ji, Wen-Fang
Yang, Ming
Zheng, Zi-Zheng
Xia, Ning-Shao
author_sort Tang, Zi-Min
collection PubMed
description The hepatitis E virus (HEV) is one of the main causes of enterically transmitted hepatitis worldwide. Although the mortality rates associated with HEV are generally low, they can be up to 28% in HEV-infected pregnant women, and the elderly are more susceptible. The reasons for this selective severity are unclear, partially because there is no suitable, easy-to-use model in which to study HEV infection. Non-human primates and standard swine have been identified as being sensitive to infection with HEV and have been used for HEV infection studies. However, studies in these animals have been limited by high housing costs and the difficulty of manipulating these animals. In the current study, we established a model of HEV infection using Bama miniature swine. The model is easy to use and is sensitive to infections with HEV genotypes 3 and 4, which are classified as zoonotic HEVs. In this model, infection of Bama miniature swine with HEV genotypes 3 and 4 caused the typical features. All Bama miniature swine that were infected with HEV genotypes 3 and 4 exhibited significant HEV viremia, shedding, anti-HEV antibody responses and partial liver inflammation. Bama miniature swine may serve as an alternative to standard swine models for the study of zoonotic HEV infection and HEV genotype specificity research.
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spelling pubmed-49892272016-08-30 The Bama miniature swine is susceptible to experimental HEV infection Tang, Zi-Min Wang, Si-Ling Ying, Dong Wen, Gui-Ping Cai, Wei Zhang, Ke Ji, Wen-Fang Yang, Ming Zheng, Zi-Zheng Xia, Ning-Shao Sci Rep Article The hepatitis E virus (HEV) is one of the main causes of enterically transmitted hepatitis worldwide. Although the mortality rates associated with HEV are generally low, they can be up to 28% in HEV-infected pregnant women, and the elderly are more susceptible. The reasons for this selective severity are unclear, partially because there is no suitable, easy-to-use model in which to study HEV infection. Non-human primates and standard swine have been identified as being sensitive to infection with HEV and have been used for HEV infection studies. However, studies in these animals have been limited by high housing costs and the difficulty of manipulating these animals. In the current study, we established a model of HEV infection using Bama miniature swine. The model is easy to use and is sensitive to infections with HEV genotypes 3 and 4, which are classified as zoonotic HEVs. In this model, infection of Bama miniature swine with HEV genotypes 3 and 4 caused the typical features. All Bama miniature swine that were infected with HEV genotypes 3 and 4 exhibited significant HEV viremia, shedding, anti-HEV antibody responses and partial liver inflammation. Bama miniature swine may serve as an alternative to standard swine models for the study of zoonotic HEV infection and HEV genotype specificity research. Nature Publishing Group 2016-08-18 /pmc/articles/PMC4989227/ /pubmed/27534702 http://dx.doi.org/10.1038/srep31813 Text en Copyright © 2016, The Author(s) http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
spellingShingle Article
Tang, Zi-Min
Wang, Si-Ling
Ying, Dong
Wen, Gui-Ping
Cai, Wei
Zhang, Ke
Ji, Wen-Fang
Yang, Ming
Zheng, Zi-Zheng
Xia, Ning-Shao
The Bama miniature swine is susceptible to experimental HEV infection
title The Bama miniature swine is susceptible to experimental HEV infection
title_full The Bama miniature swine is susceptible to experimental HEV infection
title_fullStr The Bama miniature swine is susceptible to experimental HEV infection
title_full_unstemmed The Bama miniature swine is susceptible to experimental HEV infection
title_short The Bama miniature swine is susceptible to experimental HEV infection
title_sort bama miniature swine is susceptible to experimental hev infection
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4989227/
https://www.ncbi.nlm.nih.gov/pubmed/27534702
http://dx.doi.org/10.1038/srep31813
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