The Q-rich/PST domain of the AHR regulates both ligand-induced nuclear transport and nucleocytoplasmic shuttling

The aryl hydrocarbon receptor (AHR) shuttles continuously between cytoplasm and nucleus, unless ligand-binding triggers association with the AHR nuclear translocator (ARNT) and subsequent binding to cognate DNA motifs. We have now identified Val 647 as mandatory residue for export from the nucleus a...

Descripción completa

Detalles Bibliográficos
Autores principales: Tkachenko, Anna, Henkler, Frank, Brinkmann, Joep, Sowada, Juliane, Genkinger, Doris, Kern, Christian, Tralau, Tewes, Luch, Andreas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4989234/
https://www.ncbi.nlm.nih.gov/pubmed/27535013
http://dx.doi.org/10.1038/srep32009

Ejemplares similares

Ejemplares similares