Developing an Acidic Residue Reactive and Sulfoxide-Containing MS-Cleavable Homobifunctional Cross-Linker for Probing Protein–Protein Interactions

[Image: see text] Cross-linking mass spectrometry (XL-MS) has become a powerful strategy for defining protein–protein interactions and elucidating architectures of large protein complexes. However, one of the inherent challenges in MS analysis of cross-linked peptides is their unambiguous identifica...

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Detalles Bibliográficos
Autores principales: Gutierrez, Craig B., Yu, Clinton, Novitsky, Eric J., Huszagh, Alexander S., Rychnovsky, Scott D., Huang, Lan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2016
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4989248/
https://www.ncbi.nlm.nih.gov/pubmed/27417384
http://dx.doi.org/10.1021/acs.analchem.6b02240

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