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Block Copolymer Membranes for Efficient Capture of a Chemotherapy Drug

[Image: see text] We introduce the use of block copolymer membranes for an emerging application, “drug capture”. The polymer is incorporated in a new class of biomedical devices, referred to as ChemoFilter, which is an image-guided temporarily deployable endovascular device designed to increase the...

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Autores principales: Chen, X. Chelsea, Oh, Hee Jeung, Yu, Jay F., Yang, Jeffrey K., Petzetakis, Nikos, Patel, Anand S., Hetts, Steven W., Balsara, Nitash P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2016
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4989249/
https://www.ncbi.nlm.nih.gov/pubmed/27547493
http://dx.doi.org/10.1021/acsmacrolett.6b00459
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author Chen, X. Chelsea
Oh, Hee Jeung
Yu, Jay F.
Yang, Jeffrey K.
Petzetakis, Nikos
Patel, Anand S.
Hetts, Steven W.
Balsara, Nitash P.
author_facet Chen, X. Chelsea
Oh, Hee Jeung
Yu, Jay F.
Yang, Jeffrey K.
Petzetakis, Nikos
Patel, Anand S.
Hetts, Steven W.
Balsara, Nitash P.
author_sort Chen, X. Chelsea
collection PubMed
description [Image: see text] We introduce the use of block copolymer membranes for an emerging application, “drug capture”. The polymer is incorporated in a new class of biomedical devices, referred to as ChemoFilter, which is an image-guided temporarily deployable endovascular device designed to increase the efficacy of chemotherapy-based cancer treatment. We show that block copolymer membranes consisting of functional sulfonated polystyrene end blocks and a structural polyethylene middle block (S-SES) are capable of capturing doxorubicin, a chemotherapy drug. We focus on the relationship between morphology of the membrane in the ChemoFilter device and efficacy of doxorubicin capture measured in vitro. Using small-angle X-ray scattering and cryogenic scanning transmission electron microscopy, we discovered that rapid doxorubicin capture is associated with the presence of water-rich channels in the lamellar-forming S-SES membranes in aqueous environment.
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spelling pubmed-49892492016-08-19 Block Copolymer Membranes for Efficient Capture of a Chemotherapy Drug Chen, X. Chelsea Oh, Hee Jeung Yu, Jay F. Yang, Jeffrey K. Petzetakis, Nikos Patel, Anand S. Hetts, Steven W. Balsara, Nitash P. ACS Macro Lett [Image: see text] We introduce the use of block copolymer membranes for an emerging application, “drug capture”. The polymer is incorporated in a new class of biomedical devices, referred to as ChemoFilter, which is an image-guided temporarily deployable endovascular device designed to increase the efficacy of chemotherapy-based cancer treatment. We show that block copolymer membranes consisting of functional sulfonated polystyrene end blocks and a structural polyethylene middle block (S-SES) are capable of capturing doxorubicin, a chemotherapy drug. We focus on the relationship between morphology of the membrane in the ChemoFilter device and efficacy of doxorubicin capture measured in vitro. Using small-angle X-ray scattering and cryogenic scanning transmission electron microscopy, we discovered that rapid doxorubicin capture is associated with the presence of water-rich channels in the lamellar-forming S-SES membranes in aqueous environment. American Chemical Society 2016-07-23 2016-08-16 /pmc/articles/PMC4989249/ /pubmed/27547493 http://dx.doi.org/10.1021/acsmacrolett.6b00459 Text en Copyright © 2016 American Chemical Society This is an open access article published under an ACS AuthorChoice License (http://pubs.acs.org/page/policy/authorchoice_termsofuse.html) , which permits copying and redistribution of the article or any adaptations for non-commercial purposes.
spellingShingle Chen, X. Chelsea
Oh, Hee Jeung
Yu, Jay F.
Yang, Jeffrey K.
Petzetakis, Nikos
Patel, Anand S.
Hetts, Steven W.
Balsara, Nitash P.
Block Copolymer Membranes for Efficient Capture of a Chemotherapy Drug
title Block Copolymer Membranes for Efficient Capture of a Chemotherapy Drug
title_full Block Copolymer Membranes for Efficient Capture of a Chemotherapy Drug
title_fullStr Block Copolymer Membranes for Efficient Capture of a Chemotherapy Drug
title_full_unstemmed Block Copolymer Membranes for Efficient Capture of a Chemotherapy Drug
title_short Block Copolymer Membranes for Efficient Capture of a Chemotherapy Drug
title_sort block copolymer membranes for efficient capture of a chemotherapy drug
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4989249/
https://www.ncbi.nlm.nih.gov/pubmed/27547493
http://dx.doi.org/10.1021/acsmacrolett.6b00459
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