Cargando…
Synovial Fluid C-reactive Protein as a Diagnostic Marker for Periprosthetic Joint Infection: A Systematic Review and Meta-analysis
BACKGROUND: Periprosthetic joint infection (PJI) is the main cause of failure following total joint arthroplasty. Until now, the diagnosis of PJI is still confronted with technical limitations, and the question of whether synovial fluid biomarker, C-reactive protein (CRP), can provide high value in...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Medknow Publications & Media Pvt Ltd
2016
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4989431/ https://www.ncbi.nlm.nih.gov/pubmed/27503025 http://dx.doi.org/10.4103/0366-6999.187857 |
_version_ | 1782448569835323392 |
---|---|
author | Wang, Chi Wang, Qi Li, Rui Duan, Jin-Yan Wang, Cheng-Bin |
author_facet | Wang, Chi Wang, Qi Li, Rui Duan, Jin-Yan Wang, Cheng-Bin |
author_sort | Wang, Chi |
collection | PubMed |
description | BACKGROUND: Periprosthetic joint infection (PJI) is the main cause of failure following total joint arthroplasty. Until now, the diagnosis of PJI is still confronted with technical limitations, and the question of whether synovial fluid biomarker, C-reactive protein (CRP), can provide high value in the diagnosis of PJI remains unanswered and, therefore, was the aim of the study. METHODS: First, we conducted a systematic review on CRP in the diagnosis of PJI by searching online databases using keywords such as “periprosthetic joint infection”, “synovial fluid”, and “C-reactive protein”. Eligible studies providing sufficient data to construct 2 × 2 contingency tables were then selected based on the list of criteria and the quality of included studies was assessed subsequently. Finally, the reported sensitivity, specificity, diagnostic odds ratio (DOR), summary receiver operating characteristic (SROC) curve, and the area under the SROC (AUSROC) were pooled together and used to evaluate overall diagnostic performance. RESULTS: Seven studies were included in our review, six of which comprising a total of 456 participants were further investigated in our meta-analysis. The pooled sensitivity, specificity, and DOR were 0.92 (95% confidence interval [CI]: 0.86–0.96), 0.90 (95% CI: 0.87–0.93), and 101.40 (95% CI: 48.07–213.93), respectively. The AUSROC was 0.9663 (standard error, 0.0113). CONCLUSIONS: Synovial fluid CRP is a good biomarker for the diagnosis of PJI with high sensitivity and specificity. |
format | Online Article Text |
id | pubmed-4989431 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Medknow Publications & Media Pvt Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-49894312016-09-09 Synovial Fluid C-reactive Protein as a Diagnostic Marker for Periprosthetic Joint Infection: A Systematic Review and Meta-analysis Wang, Chi Wang, Qi Li, Rui Duan, Jin-Yan Wang, Cheng-Bin Chin Med J (Engl) Meta Analysis BACKGROUND: Periprosthetic joint infection (PJI) is the main cause of failure following total joint arthroplasty. Until now, the diagnosis of PJI is still confronted with technical limitations, and the question of whether synovial fluid biomarker, C-reactive protein (CRP), can provide high value in the diagnosis of PJI remains unanswered and, therefore, was the aim of the study. METHODS: First, we conducted a systematic review on CRP in the diagnosis of PJI by searching online databases using keywords such as “periprosthetic joint infection”, “synovial fluid”, and “C-reactive protein”. Eligible studies providing sufficient data to construct 2 × 2 contingency tables were then selected based on the list of criteria and the quality of included studies was assessed subsequently. Finally, the reported sensitivity, specificity, diagnostic odds ratio (DOR), summary receiver operating characteristic (SROC) curve, and the area under the SROC (AUSROC) were pooled together and used to evaluate overall diagnostic performance. RESULTS: Seven studies were included in our review, six of which comprising a total of 456 participants were further investigated in our meta-analysis. The pooled sensitivity, specificity, and DOR were 0.92 (95% confidence interval [CI]: 0.86–0.96), 0.90 (95% CI: 0.87–0.93), and 101.40 (95% CI: 48.07–213.93), respectively. The AUSROC was 0.9663 (standard error, 0.0113). CONCLUSIONS: Synovial fluid CRP is a good biomarker for the diagnosis of PJI with high sensitivity and specificity. Medknow Publications & Media Pvt Ltd 2016-08-20 /pmc/articles/PMC4989431/ /pubmed/27503025 http://dx.doi.org/10.4103/0366-6999.187857 Text en Copyright: © 2016 Chinese Medical Journal http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms. |
spellingShingle | Meta Analysis Wang, Chi Wang, Qi Li, Rui Duan, Jin-Yan Wang, Cheng-Bin Synovial Fluid C-reactive Protein as a Diagnostic Marker for Periprosthetic Joint Infection: A Systematic Review and Meta-analysis |
title | Synovial Fluid C-reactive Protein as a Diagnostic Marker for Periprosthetic Joint Infection: A Systematic Review and Meta-analysis |
title_full | Synovial Fluid C-reactive Protein as a Diagnostic Marker for Periprosthetic Joint Infection: A Systematic Review and Meta-analysis |
title_fullStr | Synovial Fluid C-reactive Protein as a Diagnostic Marker for Periprosthetic Joint Infection: A Systematic Review and Meta-analysis |
title_full_unstemmed | Synovial Fluid C-reactive Protein as a Diagnostic Marker for Periprosthetic Joint Infection: A Systematic Review and Meta-analysis |
title_short | Synovial Fluid C-reactive Protein as a Diagnostic Marker for Periprosthetic Joint Infection: A Systematic Review and Meta-analysis |
title_sort | synovial fluid c-reactive protein as a diagnostic marker for periprosthetic joint infection: a systematic review and meta-analysis |
topic | Meta Analysis |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4989431/ https://www.ncbi.nlm.nih.gov/pubmed/27503025 http://dx.doi.org/10.4103/0366-6999.187857 |
work_keys_str_mv | AT wangchi synovialfluidcreactiveproteinasadiagnosticmarkerforperiprostheticjointinfectionasystematicreviewandmetaanalysis AT wangqi synovialfluidcreactiveproteinasadiagnosticmarkerforperiprostheticjointinfectionasystematicreviewandmetaanalysis AT lirui synovialfluidcreactiveproteinasadiagnosticmarkerforperiprostheticjointinfectionasystematicreviewandmetaanalysis AT duanjinyan synovialfluidcreactiveproteinasadiagnosticmarkerforperiprostheticjointinfectionasystematicreviewandmetaanalysis AT wangchengbin synovialfluidcreactiveproteinasadiagnosticmarkerforperiprostheticjointinfectionasystematicreviewandmetaanalysis |