Cargando…

Single-cell RNA-seq reveals novel regulators of human embryonic stem cell differentiation to definitive endoderm

BACKGROUND: Human pluripotent stem cells offer the best available model to study the underlying cellular and molecular mechanisms of human embryonic lineage specification. However, it is not fully understood how individual stem cells exit the pluripotent state and transition towards their respective...

Descripción completa

Detalles Bibliográficos
Autores principales:	Chu, Li-Fang, Leng, Ning, Zhang, Jue, Hou, Zhonggang, Mamott, Daniel, Vereide, David T., Choi, Jeea, Kendziorski, Christina, Stewart, Ron, Thomson, James A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2016
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4989499/ https://www.ncbi.nlm.nih.gov/pubmed/27534536 http://dx.doi.org/10.1186/s13059-016-1033-x

Ejemplares similares

OEFinder: a user interface to identify and visualize ordering effects in single-cell RNA-seq data
por: Leng, Ning, et al.
Publicado: (2016)

An In Vitro Human Segmentation Clock Model Derived from Embryonic Stem Cells
por: Chu, Li-Fang, et al.
Publicado: (2019)

Oscope identifies oscillatory genes in unsynchronized single cell RNA-seq experiments
por: Leng, Ning, et al.
Publicado: (2015)

Stauprimide Priming of Human Embryonic Stem Cells toward Definitive Endoderm
por: Tahamtani, Yaser, et al.
Publicado: (2014)

SCnorm: robust normalization of single-cell RNA-seq data
por: Bacher, Rhonda, et al.
Publicado: (2017)

Human Embryonic and Rat Adult Stem Cells with Primitive Endoderm-Like Phenotype Can Be Fated to Definitive Endoderm, and Finally Hepatocyte-Like Cells
por: Roelandt, Philip, et al.
Publicado: (2010)

Collagen Type I Improves the Differentiation of Human Embryonic Stem Cells towards Definitive Endoderm
por: Rasmussen, Camilla Holzmann, et al.
Publicado: (2015)

A statistical approach for identifying differential distributions in single-cell RNA-seq experiments
por: Korthauer, Keegan D., et al.
Publicado: (2016)

Endogenous suppression of WNT signalling in human embryonic stem cells leads to low differentiation propensity towards definitive endoderm
por: Dziedzicka, Dominika, et al.
Publicado: (2021)

Hydrocortisone Promotes Differentiation of Mouse Embryonic Stem Cell-Derived Definitive Endoderm toward Lung Alveolar Epithelial Cells
por: Mokhber Dezfouli, Mohammad Reza, et al.
Publicado: (2019)

Hydrocortisone Promotes Differentiation of Mouse Embryonic Stem Cell-Derived Definitive Endoderm toward Lung Alveolar Epithelial Cells
por: Mokhber Dezfouli, Mohammad Reza, et al.
Publicado: (2021)

Effects of low doses of methylmercury (MeHg) exposure on definitive endoderm cell differentiation in human embryonic stem cells
por: Li, Bai, et al.
Publicado: (2023)

Potential for Pancreatic Maturation of Differentiating Human Embryonic Stem Cells Is Sensitive to the Specific Pathway of Definitive Endoderm Commitment
por: Jaramillo, Maria, et al.
Publicado: (2014)

Transcriptome dataset for RNA-seq analysis of axolotl embryonic oropharyngeal endoderm explants
por: Marazzi, Lauren, et al.
Publicado: (2020)

Reproducibility across single-cell RNA-seq protocols for spatial ordering analysis
por: Seirup, Morten, et al.
Publicado: (2020)

Insulin-Producing Cells Derived from Human Embryonic Stem Cells: Comparison of Definitive Endoderm- and Nestin-Positive Progenitor-Based Differentiation Strategies
por: Wei, Rui, et al.
Publicado: (2013)

Protocol for siRNA-mediated TET1 knockdown during differentiation of human embryonic stem cells into definitive endoderm cells
por: Liufu, Zhongqi, et al.
Publicado: (2023)

Concerted cell divisions in embryonic visceral endoderm guide anterior visceral endoderm migration
por: Antonica, Francesco, et al.
Publicado: (2019)

Enhancing biological signals and detection rates in single-cell RNA-seq experiments with cDNA library equalization
por: Bacher, Rhonda, et al.
Publicado: (2021)

Argonaute 2 Is Required for Extra-embryonic Endoderm Differentiation of Mouse Embryonic Stem Cells
por: Ngondo, Richard Patryk, et al.
Publicado: (2018)

Definitive Endodermal Cells Supply an in vitro Source of Mesenchymal Stem/Stromal Cells
por: Zhang, Yumeng, et al.
Publicado: (2023)

Mild electrical stimulation with heat shock guides differentiation of embryonic stem cells into Pdx1-expressing cells within the definitive endoderm
por: Koga, Tomoaki, et al.
Publicado: (2017)

Polycomb enables primitive endoderm lineage priming in embryonic stem cells
por: Illingworth, Robert S, et al.
Publicado: (2016)

Tumor Suppressors and Endodermal Differentiation of P19 Embryonic Stem Cells
por: Kanungo, Jyotshna
Publicado: (2015)

Mitochondrial homeostasis regulates definitive endoderm differentiation of human pluripotent stem cells
por: Lv, Jing, et al.
Publicado: (2022)

In silico discovery of small molecules for efficient stem cell differentiation into definitive endoderm
por: Novakovsky, Gherman, et al.
Publicado: (2023)

A novel chemically directed route for the generation of definitive endoderm from human embryonic stem cells based on inhibition of GSK-3
por: Bone, Heather K., et al.
Publicado: (2011)

A human pluripotent stem cell platform for assessing developmental neural toxicity screening
por: Hou, Zhonggang, et al.
Publicado: (2013)

Automated minute scale RNA-seq of pluripotent stem cell differentiation reveals early divergence of human and mouse gene expression kinetics
por: Barry, Christopher, et al.
Publicado: (2019)

EBSeq-HMM: a Bayesian approach for identifying gene-expression changes in ordered RNA-seq experiments
por: Leng, Ning, et al.
Publicado: (2015)

Characteristics of the Endoderm: Embryonic and Extraembryonic in Mouse
por: Familari, Mary
Publicado: (2006)

STELLA Facilitates Differentiation of Germ Cell and Endodermal Lineages of Human Embryonic Stem Cells
por: Wongtrakoongate, Patompon, et al.
Publicado: (2013)

Modulation of the Pentose Phosphate Pathway Induces Endodermal Differentiation in Embryonic Stem Cells
por: Manganelli, Genesia, et al.
Publicado: (2012)

Differentiation of Mouse Embryonic Stem Cells into Endoderm without Embryoid Body Formation
por: Kim, Peter T. W., et al.
Publicado: (2010)

Mga safeguards embryonic stem cells from acquiring extraembryonic endoderm fates
por: Qin, Jinzhong, et al.
Publicado: (2021)

Trendy: segmented regression analysis of expression dynamics in high-throughput ordered profiling experiments
por: Bacher, Rhonda, et al.
Publicado: (2018)

A Comparative Analysis of Extra-Embryonic Endoderm Cell Lines
por: Brown, Kemar, et al.
Publicado: (2010)

DMSO Efficiently Down Regulates Pluripotency Genes in Human Embryonic Stem Cells during Definitive Endoderm Derivation and Increases the Proficiency of Hepatic Differentiation
por: Czysz, Katherine, et al.
Publicado: (2015)

Emergence and patterning dynamics of mouse-definitive endoderm
por: Pour, Maayan, et al.
Publicado: (2021)

Epigenetic Induction of Definitive and Pancreatic Endoderm Cell Fate in Human Fibroblasts
por: Sambathkumar, Rangarajan, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_lmjs57ldop4i11c90r0s5egslp