In situ expression of (R)-carbonyl reductase rebalancing an asymmetric pathway improves stereoconversion efficiency of racemic mixture to (S)-phenyl-1,2-ethanediol in Candida parapsilosis CCTCC M203011

BACKGROUND: Candida parapsilosis (R)-carbonyl reductase (RCR) and (S)-carbonyl reductase (SCR) are involved in the stereoconversion of racemic (R,S)-1-phenyl-1,2-ethanediol (PED) to its (S)-isomer. RCR catalyzes (R)-PED to 2-hydroxyacetophenone (2-HAP), and SCR catalyzes 2-HAP to (S)-PED. However, t...

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Detalles Bibliográficos
Autores principales: Zhang, Rongzhen, Wang, Lei, Xu, Yan, Liang, Hongbo, Zhou, Xiaotian, Jiang, Jiawei, Li, Yaohui, Xiao, Rong, Ni, Ye
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4989518/
https://www.ncbi.nlm.nih.gov/pubmed/27534936
http://dx.doi.org/10.1186/s12934-016-0539-y

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