The pharmacokinetics and toxicity of morning vs. evening tobramycin dosing for pulmonary exacerbations of cystic fibrosis: A randomised comparison

BACKGROUND: Circadian variation in renal toxicity of aminoglycosides has been demonstrated in animal and human studies. People with CF are frequently prescribed aminoglycosides. Altered pharmacokinetics of aminoglycosides are predictive of toxicity. AIM: To investigate whether the time of day of ami...

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Detalles Bibliográficos
Autores principales: Prayle, A.P., Jain, K., Touw, D.J., Koch, B.C.P., Knox, A.J., Watson, A., Smyth, A.R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2016
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4989998/
https://www.ncbi.nlm.nih.gov/pubmed/26282839
http://dx.doi.org/10.1016/j.jcf.2015.07.012

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