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The role of the Mre11–Rad50–Nbs1 complex in double-strand break repair—facts and myths
Homologous recombination (HR) initiates double-strand break (DSB) repair by digesting 5′-termini at DSBs, the biochemical reaction called DSB resection, during which DSBs are processed by nucleases to generate 3′ single-strand DNA. Rad51 recombinase polymerizes along resected DNA, and the resulting...
Autores principales: | Takeda, Shunichi, Hoa, Nguyen Ngoc, Sasanuma, Hiroyuki |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4990115/ https://www.ncbi.nlm.nih.gov/pubmed/27311583 http://dx.doi.org/10.1093/jrr/rrw034 |
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