Platelet Adhesion to Podoplanin Under Flow is Mediated by the Receptor CLEC-2 and Stabilised by Src/Syk-Dependent Platelet Signalling

Platelet-specific deletion of CLEC-2, which signals through Src and Syk kinases, or global deletion of its ligand podoplanin results in blood-filled lymphatics during mouse development. Platelet-specific Syk deficiency phenocopies this defect, indicating that platelet activation is required for lymp...

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Detalles Bibliográficos
Autores principales: Navarro-Núñez, Leyre, Pollitt, Alice Y., Lowe, Kate, Latif, Arusa, Nash, Gerard B., Watson, Steve P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Schattauer 2015
Materias:
Cellular Signalling and Proteolysis
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4990172/
https://www.ncbi.nlm.nih.gov/pubmed/25694214
http://dx.doi.org/10.1160/TH14-09-0762

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4990172/
https://www.ncbi.nlm.nih.gov/pubmed/25694214
http://dx.doi.org/10.1160/TH14-09-0762

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