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A Tmprss2-CreER(T2) Knock-In Mouse Model for Cancer Genetic Studies on Prostate and Colon
Fusion between TMPRSS2 and ERG, placing ERG under the control of the TMPRSS2 promoter, is the most frequent genetic alteration in prostate cancer, present in 40–50% of cases. The fusion event is an early, if not initiating, event in prostate cancer, implicating the TMPRSS2-positive prostate epitheli...
Autores principales: | Gao, Dong, Zhan, Yu, Di, Wei, Moore, Amanda R., Sher, Jessica J., Guan, Youxin, Wang, Shangqian, Zhang, Zeda, Murphy, Devan A., Sawyers, Charles L., Chi, Ping, Chen, Yu |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4990297/ https://www.ncbi.nlm.nih.gov/pubmed/27536883 http://dx.doi.org/10.1371/journal.pone.0161084 |
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