Tyrosinase-Cre-Mediated Deletion of the Autophagy Gene Atg7 Leads to Accumulation of the RPE65 Variant M450 in the Retinal Pigment Epithelium of C57BL/6 Mice

Targeted gene knockout mouse models have helped to identify roles of autophagy in many tissues. Here, we investigated the retinal pigment epithelium (RPE) of Atg7(f/f) Tyr-Cre mice (on a C57BL/6 background), in which Cre recombinase is expressed under the control of the tyrosinase promoter to delete...

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Detalles Bibliográficos
Autores principales: Sukseree, Supawadee, Chen, Ying-Ting, Laggner, Maria, Gruber, Florian, Petit, Valérie, Nagelreiter, Ionela-Mariana, Mlitz, Veronika, Rossiter, Heidemarie, Pollreisz, Andreas, Schmidt-Erfurth, Ursula, Larue, Lionel, Tschachler, Erwin, Eckhart, Leopold
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4990303/
https://www.ncbi.nlm.nih.gov/pubmed/27537685
http://dx.doi.org/10.1371/journal.pone.0161640

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