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Modification of β-Sheet Forming Peptide Hydrophobic Face: Effect on Self-Assembly and Gelation
[Image: see text] β-Sheet forming peptides have attracted significant interest for the design of hydrogels for biomedical applications. One of the main challenges is the control and understanding of the correlations between peptide molecular structure, the morphology, and topology of the fiber and n...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American
Chemical Society
2016
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4990315/ https://www.ncbi.nlm.nih.gov/pubmed/27089379 http://dx.doi.org/10.1021/acs.langmuir.5b03841 |
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author | Elsawy, Mohamed A. Smith, Andrew M. Hodson, Nigel Squires, Adam Miller, Aline F. Saiani, Alberto |
author_facet | Elsawy, Mohamed A. Smith, Andrew M. Hodson, Nigel Squires, Adam Miller, Aline F. Saiani, Alberto |
author_sort | Elsawy, Mohamed A. |
collection | PubMed |
description | [Image: see text] β-Sheet forming peptides have attracted significant interest for the design of hydrogels for biomedical applications. One of the main challenges is the control and understanding of the correlations between peptide molecular structure, the morphology, and topology of the fiber and network formed as well as the macroscopic properties of the hydrogel obtained. In this work, we have investigated the effect that functionalizing these peptides through their hydrophobic face has on their self-assembly and gelation. Our results show that the modification of the hydrophobic face results in a partial loss of the extended β-sheet conformation of the peptide and a significant change in fiber morphology from straight to kinked. As a consequence, the ability of these fibers to associate along their length and form large bundles is reduced. These structural changes (fiber structure and network topology) significantly affect the mechanical properties of the hydrogels (shear modulus and elasticity). |
format | Online Article Text |
id | pubmed-4990315 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | American
Chemical Society |
record_format | MEDLINE/PubMed |
spelling | pubmed-49903152016-08-19 Modification of β-Sheet Forming Peptide Hydrophobic Face: Effect on Self-Assembly and Gelation Elsawy, Mohamed A. Smith, Andrew M. Hodson, Nigel Squires, Adam Miller, Aline F. Saiani, Alberto Langmuir [Image: see text] β-Sheet forming peptides have attracted significant interest for the design of hydrogels for biomedical applications. One of the main challenges is the control and understanding of the correlations between peptide molecular structure, the morphology, and topology of the fiber and network formed as well as the macroscopic properties of the hydrogel obtained. In this work, we have investigated the effect that functionalizing these peptides through their hydrophobic face has on their self-assembly and gelation. Our results show that the modification of the hydrophobic face results in a partial loss of the extended β-sheet conformation of the peptide and a significant change in fiber morphology from straight to kinked. As a consequence, the ability of these fibers to associate along their length and form large bundles is reduced. These structural changes (fiber structure and network topology) significantly affect the mechanical properties of the hydrogels (shear modulus and elasticity). American Chemical Society 2016-04-18 2016-05-17 /pmc/articles/PMC4990315/ /pubmed/27089379 http://dx.doi.org/10.1021/acs.langmuir.5b03841 Text en Copyright © 2016 American Chemical Society This is an open access article published under a Creative Commons Attribution (CC-BY) License (http://pubs.acs.org/page/policy/authorchoice_ccby_termsofuse.html) , which permits unrestricted use, distribution and reproduction in any medium, provided the author and source are cited. |
spellingShingle | Elsawy, Mohamed A. Smith, Andrew M. Hodson, Nigel Squires, Adam Miller, Aline F. Saiani, Alberto Modification of β-Sheet Forming Peptide Hydrophobic Face: Effect on Self-Assembly and Gelation |
title | Modification of β-Sheet Forming Peptide
Hydrophobic Face: Effect on Self-Assembly and Gelation |
title_full | Modification of β-Sheet Forming Peptide
Hydrophobic Face: Effect on Self-Assembly and Gelation |
title_fullStr | Modification of β-Sheet Forming Peptide
Hydrophobic Face: Effect on Self-Assembly and Gelation |
title_full_unstemmed | Modification of β-Sheet Forming Peptide
Hydrophobic Face: Effect on Self-Assembly and Gelation |
title_short | Modification of β-Sheet Forming Peptide
Hydrophobic Face: Effect on Self-Assembly and Gelation |
title_sort | modification of β-sheet forming peptide
hydrophobic face: effect on self-assembly and gelation |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4990315/ https://www.ncbi.nlm.nih.gov/pubmed/27089379 http://dx.doi.org/10.1021/acs.langmuir.5b03841 |
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