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Antibacterial coating on biocomposites for cranio-facial reconstruction
BACKGROUND AND AIMS: Despite the fact that implants are sterilized, antiseptic techniques are applied and systemic antibiotics are routinely administered prior to and after craniofacial surgery, infection rates between 3% and 40% are still reported for alloplastic implants, urging for implant remova...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Iuliu Hatieganu University of Medicine and Pharmacy
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4990441/ https://www.ncbi.nlm.nih.gov/pubmed/27547065 http://dx.doi.org/10.15386/cjmed-599 |
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author | LAZAR, MADALINA ANCA VODNAR, DAN PRODAN, DOINA ROTARU, HORATIU ROMAN, CALIN RARES SORCOI, LIDIA ADRIANA BACIUT, GRIGORE CAMPIAN, RADU SEPTIMIU |
author_facet | LAZAR, MADALINA ANCA VODNAR, DAN PRODAN, DOINA ROTARU, HORATIU ROMAN, CALIN RARES SORCOI, LIDIA ADRIANA BACIUT, GRIGORE CAMPIAN, RADU SEPTIMIU |
author_sort | LAZAR, MADALINA ANCA |
collection | PubMed |
description | BACKGROUND AND AIMS: Despite the fact that implants are sterilized, antiseptic techniques are applied and systemic antibiotics are routinely administered prior to and after craniofacial surgery, infection rates between 3% and 40% are still reported for alloplastic implants, urging for implant removal. The present study focuses on the development of a fiber-reinforced composite (FRC) implant for craniofacial reconstruction with antimicrobial properties. METHODS: A new fiber-reinforced composite coated with gentamicin was developed and tested for bacterial adherence and antibacterial efficiency, using two of the most involved bacterial strains in the postoperative infections: Staphylococcus aureus and Pseudomonas aeruginosa. RESULTS: Bacteria were efficiently inactivated in direct contact with gentamicin coatings (p<0.05). The inhibition zone for Staphylococcus aureus ranged from 17.21 mm to 20.13 mm and for Pseudomonas aeruginosa ranged from 12.93 mm to 15.33 mm. Although no significant statistical results were found for bacterial adhesion and gentamicin concentration, (Staphylococcus aureus: β= −0.974; p=0.144>0.05 and Pseudomonas aeruginosa: β = −0.921; p=0.255>0.05), a negative relation was observed, indicating the reversed relation between the antibiotic dosage and the bacterial adherence. CONCLUSION: The results of the two applied microbiological protocols used in the study suggested that gentamicin eluting coating inhibited not only the bacterial growth, but also led to a lower initial bacterial adhesion to the surface of the implant. Thus, antibiotic coating of craniofacial implants may reduce the infection rate related to reconstructive surgery. |
format | Online Article Text |
id | pubmed-4990441 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Iuliu Hatieganu University of Medicine and Pharmacy |
record_format | MEDLINE/PubMed |
spelling | pubmed-49904412016-08-19 Antibacterial coating on biocomposites for cranio-facial reconstruction LAZAR, MADALINA ANCA VODNAR, DAN PRODAN, DOINA ROTARU, HORATIU ROMAN, CALIN RARES SORCOI, LIDIA ADRIANA BACIUT, GRIGORE CAMPIAN, RADU SEPTIMIU Clujul Med Original Research BACKGROUND AND AIMS: Despite the fact that implants are sterilized, antiseptic techniques are applied and systemic antibiotics are routinely administered prior to and after craniofacial surgery, infection rates between 3% and 40% are still reported for alloplastic implants, urging for implant removal. The present study focuses on the development of a fiber-reinforced composite (FRC) implant for craniofacial reconstruction with antimicrobial properties. METHODS: A new fiber-reinforced composite coated with gentamicin was developed and tested for bacterial adherence and antibacterial efficiency, using two of the most involved bacterial strains in the postoperative infections: Staphylococcus aureus and Pseudomonas aeruginosa. RESULTS: Bacteria were efficiently inactivated in direct contact with gentamicin coatings (p<0.05). The inhibition zone for Staphylococcus aureus ranged from 17.21 mm to 20.13 mm and for Pseudomonas aeruginosa ranged from 12.93 mm to 15.33 mm. Although no significant statistical results were found for bacterial adhesion and gentamicin concentration, (Staphylococcus aureus: β= −0.974; p=0.144>0.05 and Pseudomonas aeruginosa: β = −0.921; p=0.255>0.05), a negative relation was observed, indicating the reversed relation between the antibiotic dosage and the bacterial adherence. CONCLUSION: The results of the two applied microbiological protocols used in the study suggested that gentamicin eluting coating inhibited not only the bacterial growth, but also led to a lower initial bacterial adhesion to the surface of the implant. Thus, antibiotic coating of craniofacial implants may reduce the infection rate related to reconstructive surgery. Iuliu Hatieganu University of Medicine and Pharmacy 2016 2016-07-28 /pmc/articles/PMC4990441/ /pubmed/27547065 http://dx.doi.org/10.15386/cjmed-599 Text en http://creativecommons.org/licenses/by-nc-nd/4.0/ This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License |
spellingShingle | Original Research LAZAR, MADALINA ANCA VODNAR, DAN PRODAN, DOINA ROTARU, HORATIU ROMAN, CALIN RARES SORCOI, LIDIA ADRIANA BACIUT, GRIGORE CAMPIAN, RADU SEPTIMIU Antibacterial coating on biocomposites for cranio-facial reconstruction |
title | Antibacterial coating on biocomposites for cranio-facial reconstruction |
title_full | Antibacterial coating on biocomposites for cranio-facial reconstruction |
title_fullStr | Antibacterial coating on biocomposites for cranio-facial reconstruction |
title_full_unstemmed | Antibacterial coating on biocomposites for cranio-facial reconstruction |
title_short | Antibacterial coating on biocomposites for cranio-facial reconstruction |
title_sort | antibacterial coating on biocomposites for cranio-facial reconstruction |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4990441/ https://www.ncbi.nlm.nih.gov/pubmed/27547065 http://dx.doi.org/10.15386/cjmed-599 |
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