Targeted inhibition of oncogenic miR-21 maturation with designed RNA-binding proteins

The RNA Recognition Motif (RRM) is the largest family of eukaryotic RNA-binding proteins. Engineered RRMs with new specificity would provide valuable tools and an exacting test of our understanding of specificity. We have achieved the first successful re-design of the specificity of an RRM using rat...

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Detalles Bibliográficos
Autores principales: Chen, Yu, Yang, Fan, Zubovic, Lorena, Pavelitz, Tom, Yang, Wen, Godin, Katherine, Walker, Matthew, Zheng, Suxin, Macchi, Paolo, Varani, Gabriele
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4990487/
https://www.ncbi.nlm.nih.gov/pubmed/27428511
http://dx.doi.org/10.1038/nchembio.2128

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