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Establishing the precise evolutionary history of a gene improves prediction of disease-causing missense mutations

PURPOSE: Predicting the phenotypic effects of mutations has become an important application in clinical genetic diagnostics. Computational tools evaluate the behavior of the variant over evolutionary time and assume that variations seen during the course of evolution are probably benign in humans. H...

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Detalles Bibliográficos
Autores principales:	Adebali, Ogun, Reznik, Alexander O., Ory, Daniel S., Zhulin, Igor B.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2016
Materias:	Original Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4990510/ https://www.ncbi.nlm.nih.gov/pubmed/26890452 http://dx.doi.org/10.1038/gim.2015.208

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