Intra-articular interleukin-1 receptor antagonist (IL1-ra) microspheres for posttraumatic osteoarthritis: in vitro biological activity and in vivo disease modifying effect

BACKGROUND: Interleukin-1 receptor antagonist (IL-1 ra) can be disease-modifying in posttraumatic osteoarthritis (PTOA). One limitation is its short joint residence time. We hypothesized that IL-1 ra encapsulation in poly (lactide-co-glycolide) (PLGA) microspheres reduces IL-1 ra systemic absorption...

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Detalles Bibliográficos
Autores principales: Elsaid, Khaled A., Ubhe, Anand, Shaman, Ziyad, D’Souza, Gerard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2016
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4990523/
https://www.ncbi.nlm.nih.gov/pubmed/27539076
http://dx.doi.org/10.1186/s40634-016-0054-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4990523/
https://www.ncbi.nlm.nih.gov/pubmed/27539076
http://dx.doi.org/10.1186/s40634-016-0054-4

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