Circulating Extracellular Vesicles Contain miRNAs and are Released as Early Biomarkers for Cardiac Injury

Plasma-circulating microRNAs have been implicated as novel early biomarkers for myocardial infarction (MI) due to their high specificity for cardiac injury. For swift clinical translation of this potential biomarker, it is important to understand their temporal and spatial characteristics upon MI. T...

Descripción completa

Detalles Bibliográficos
Autores principales: Deddens, Janine C., Vrijsen, Krijn R., Colijn, Johanna M., Oerlemans, Martinus I., Metz, Corina H. G., van der Vlist, Els J., Nolte-’t Hoen, Esther N. M., den Ouden, Krista, Jansen Of Lorkeers, Sanne J., van der Spoel, Tycho I. G., Koudstaal, Stefan, Arkesteijn, Ger J., Wauben, Marca H. M., van Laake, Linda W., Doevendans, Pieter A., Chamuleau, Steven A. J., Sluijter, Joost P. G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2016
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4990609/
https://www.ncbi.nlm.nih.gov/pubmed/27383837
http://dx.doi.org/10.1007/s12265-016-9705-1
_version_ 1782448722327633920
author Deddens, Janine C.
Vrijsen, Krijn R.
Colijn, Johanna M.
Oerlemans, Martinus I.
Metz, Corina H. G.
van der Vlist, Els J.
Nolte-’t Hoen, Esther N. M.
den Ouden, Krista
Jansen Of Lorkeers, Sanne J.
van der Spoel, Tycho I. G.
Koudstaal, Stefan
Arkesteijn, Ger J.
Wauben, Marca H. M.
van Laake, Linda W.
Doevendans, Pieter A.
Chamuleau, Steven A. J.
Sluijter, Joost P. G.
author_facet Deddens, Janine C.
Vrijsen, Krijn R.
Colijn, Johanna M.
Oerlemans, Martinus I.
Metz, Corina H. G.
van der Vlist, Els J.
Nolte-’t Hoen, Esther N. M.
den Ouden, Krista
Jansen Of Lorkeers, Sanne J.
van der Spoel, Tycho I. G.
Koudstaal, Stefan
Arkesteijn, Ger J.
Wauben, Marca H. M.
van Laake, Linda W.
Doevendans, Pieter A.
Chamuleau, Steven A. J.
Sluijter, Joost P. G.
author_sort Deddens, Janine C.
collection PubMed
description Plasma-circulating microRNAs have been implicated as novel early biomarkers for myocardial infarction (MI) due to their high specificity for cardiac injury. For swift clinical translation of this potential biomarker, it is important to understand their temporal and spatial characteristics upon MI. Therefore, we studied the temporal release, potential source, and transportation of circulating miRNAs in different models of ischemia reperfusion (I/R) injury. We demonstrated that extracellular vesicles are released from the ischemic myocardium upon I/R injury. Moreover, we provided evidence that cardiac and muscle-specific miRNAs are transported by extracellular vesicles and are rapidly detectable in plasma. Since these vesicles are enriched for the released miRNAs and their detection precedes traditional damage markers, they hold great potential as specific early biomarkers for MI. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1007/s12265-016-9705-1) contains supplementary material, which is available to authorized users.
format Online
Article
Text
id pubmed-4990609
institution National Center for Biotechnology Information
language English
publishDate 2016
publisher Springer US
record_format MEDLINE/PubMed
spelling pubmed-49906092016-09-01 Circulating Extracellular Vesicles Contain miRNAs and are Released as Early Biomarkers for Cardiac Injury Deddens, Janine C. Vrijsen, Krijn R. Colijn, Johanna M. Oerlemans, Martinus I. Metz, Corina H. G. van der Vlist, Els J. Nolte-’t Hoen, Esther N. M. den Ouden, Krista Jansen Of Lorkeers, Sanne J. van der Spoel, Tycho I. G. Koudstaal, Stefan Arkesteijn, Ger J. Wauben, Marca H. M. van Laake, Linda W. Doevendans, Pieter A. Chamuleau, Steven A. J. Sluijter, Joost P. G. J Cardiovasc Transl Res Original Article Plasma-circulating microRNAs have been implicated as novel early biomarkers for myocardial infarction (MI) due to their high specificity for cardiac injury. For swift clinical translation of this potential biomarker, it is important to understand their temporal and spatial characteristics upon MI. Therefore, we studied the temporal release, potential source, and transportation of circulating miRNAs in different models of ischemia reperfusion (I/R) injury. We demonstrated that extracellular vesicles are released from the ischemic myocardium upon I/R injury. Moreover, we provided evidence that cardiac and muscle-specific miRNAs are transported by extracellular vesicles and are rapidly detectable in plasma. Since these vesicles are enriched for the released miRNAs and their detection precedes traditional damage markers, they hold great potential as specific early biomarkers for MI. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1007/s12265-016-9705-1) contains supplementary material, which is available to authorized users. Springer US 2016-07-06 2016 /pmc/articles/PMC4990609/ /pubmed/27383837 http://dx.doi.org/10.1007/s12265-016-9705-1 Text en © The Author(s) 2016 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Original Article
Deddens, Janine C.
Vrijsen, Krijn R.
Colijn, Johanna M.
Oerlemans, Martinus I.
Metz, Corina H. G.
van der Vlist, Els J.
Nolte-’t Hoen, Esther N. M.
den Ouden, Krista
Jansen Of Lorkeers, Sanne J.
van der Spoel, Tycho I. G.
Koudstaal, Stefan
Arkesteijn, Ger J.
Wauben, Marca H. M.
van Laake, Linda W.
Doevendans, Pieter A.
Chamuleau, Steven A. J.
Sluijter, Joost P. G.
Circulating Extracellular Vesicles Contain miRNAs and are Released as Early Biomarkers for Cardiac Injury
title Circulating Extracellular Vesicles Contain miRNAs and are Released as Early Biomarkers for Cardiac Injury
title_full Circulating Extracellular Vesicles Contain miRNAs and are Released as Early Biomarkers for Cardiac Injury
title_fullStr Circulating Extracellular Vesicles Contain miRNAs and are Released as Early Biomarkers for Cardiac Injury
title_full_unstemmed Circulating Extracellular Vesicles Contain miRNAs and are Released as Early Biomarkers for Cardiac Injury
title_short Circulating Extracellular Vesicles Contain miRNAs and are Released as Early Biomarkers for Cardiac Injury
title_sort circulating extracellular vesicles contain mirnas and are released as early biomarkers for cardiac injury
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4990609/
https://www.ncbi.nlm.nih.gov/pubmed/27383837
http://dx.doi.org/10.1007/s12265-016-9705-1
work_keys_str_mv AT deddensjaninec circulatingextracellularvesiclescontainmirnasandarereleasedasearlybiomarkersforcardiacinjury
AT vrijsenkrijnr circulatingextracellularvesiclescontainmirnasandarereleasedasearlybiomarkersforcardiacinjury
AT colijnjohannam circulatingextracellularvesiclescontainmirnasandarereleasedasearlybiomarkersforcardiacinjury
AT oerlemansmartinusi circulatingextracellularvesiclescontainmirnasandarereleasedasearlybiomarkersforcardiacinjury
AT metzcorinahg circulatingextracellularvesiclescontainmirnasandarereleasedasearlybiomarkersforcardiacinjury
AT vandervlistelsj circulatingextracellularvesiclescontainmirnasandarereleasedasearlybiomarkersforcardiacinjury
AT noltethoenesthernm circulatingextracellularvesiclescontainmirnasandarereleasedasearlybiomarkersforcardiacinjury
AT denoudenkrista circulatingextracellularvesiclescontainmirnasandarereleasedasearlybiomarkersforcardiacinjury
AT jansenoflorkeerssannej circulatingextracellularvesiclescontainmirnasandarereleasedasearlybiomarkersforcardiacinjury
AT vanderspoeltychoig circulatingextracellularvesiclescontainmirnasandarereleasedasearlybiomarkersforcardiacinjury
AT koudstaalstefan circulatingextracellularvesiclescontainmirnasandarereleasedasearlybiomarkersforcardiacinjury
AT arkesteijngerj circulatingextracellularvesiclescontainmirnasandarereleasedasearlybiomarkersforcardiacinjury
AT waubenmarcahm circulatingextracellularvesiclescontainmirnasandarereleasedasearlybiomarkersforcardiacinjury
AT vanlaakelindaw circulatingextracellularvesiclescontainmirnasandarereleasedasearlybiomarkersforcardiacinjury
AT doevendanspietera circulatingextracellularvesiclescontainmirnasandarereleasedasearlybiomarkersforcardiacinjury
AT chamuleaustevenaj circulatingextracellularvesiclescontainmirnasandarereleasedasearlybiomarkersforcardiacinjury
AT sluijterjoostpg circulatingextracellularvesiclescontainmirnasandarereleasedasearlybiomarkersforcardiacinjury

Ejemplares similares