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Endothelial cells are progenitors of cardiac pericytes and vascular smooth muscle cells

Mural cells of the vessel wall, namely pericytes and vascular smooth muscle cells, are essential for vascular integrity. The developmental sources of these cells and molecular mechanisms controlling their progenitors in the heart are only partially understood. Here we show that endocardial endotheli...

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Autores principales: Chen, Qi, Zhang, Hui, Liu, Yang, Adams, Susanne, Eilken, Hanna, Stehling, Martin, Corada, Monica, Dejana, Elisabetta, Zhou, Bin, Adams, Ralf H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4990645/
https://www.ncbi.nlm.nih.gov/pubmed/27516371
http://dx.doi.org/10.1038/ncomms12422
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author Chen, Qi
Zhang, Hui
Liu, Yang
Adams, Susanne
Eilken, Hanna
Stehling, Martin
Corada, Monica
Dejana, Elisabetta
Zhou, Bin
Adams, Ralf H.
author_facet Chen, Qi
Zhang, Hui
Liu, Yang
Adams, Susanne
Eilken, Hanna
Stehling, Martin
Corada, Monica
Dejana, Elisabetta
Zhou, Bin
Adams, Ralf H.
author_sort Chen, Qi
collection PubMed
description Mural cells of the vessel wall, namely pericytes and vascular smooth muscle cells, are essential for vascular integrity. The developmental sources of these cells and molecular mechanisms controlling their progenitors in the heart are only partially understood. Here we show that endocardial endothelial cells are progenitors of pericytes and vascular smooth muscle cells in the murine embryonic heart. Endocardial cells undergo endothelial–mesenchymal transition and convert into primitive mesenchymal progenitors expressing the platelet-derived growth factor receptors, PDGFRα and PDGFRβ. These progenitors migrate into the myocardium, differentiate and assemble the wall of coronary vessels, which requires canonical Wnt signalling involving Frizzled4, β-catenin and endothelial cell-derived Wnt ligands. Our findings identify a novel and unexpected population of progenitors for coronary mural cells with potential relevance for heart function and disease conditions.
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spelling pubmed-49906452016-09-01 Endothelial cells are progenitors of cardiac pericytes and vascular smooth muscle cells Chen, Qi Zhang, Hui Liu, Yang Adams, Susanne Eilken, Hanna Stehling, Martin Corada, Monica Dejana, Elisabetta Zhou, Bin Adams, Ralf H. Nat Commun Article Mural cells of the vessel wall, namely pericytes and vascular smooth muscle cells, are essential for vascular integrity. The developmental sources of these cells and molecular mechanisms controlling their progenitors in the heart are only partially understood. Here we show that endocardial endothelial cells are progenitors of pericytes and vascular smooth muscle cells in the murine embryonic heart. Endocardial cells undergo endothelial–mesenchymal transition and convert into primitive mesenchymal progenitors expressing the platelet-derived growth factor receptors, PDGFRα and PDGFRβ. These progenitors migrate into the myocardium, differentiate and assemble the wall of coronary vessels, which requires canonical Wnt signalling involving Frizzled4, β-catenin and endothelial cell-derived Wnt ligands. Our findings identify a novel and unexpected population of progenitors for coronary mural cells with potential relevance for heart function and disease conditions. Nature Publishing Group 2016-08-12 /pmc/articles/PMC4990645/ /pubmed/27516371 http://dx.doi.org/10.1038/ncomms12422 Text en Copyright © 2016, The Author(s) http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
spellingShingle Article
Chen, Qi
Zhang, Hui
Liu, Yang
Adams, Susanne
Eilken, Hanna
Stehling, Martin
Corada, Monica
Dejana, Elisabetta
Zhou, Bin
Adams, Ralf H.
Endothelial cells are progenitors of cardiac pericytes and vascular smooth muscle cells
title Endothelial cells are progenitors of cardiac pericytes and vascular smooth muscle cells
title_full Endothelial cells are progenitors of cardiac pericytes and vascular smooth muscle cells
title_fullStr Endothelial cells are progenitors of cardiac pericytes and vascular smooth muscle cells
title_full_unstemmed Endothelial cells are progenitors of cardiac pericytes and vascular smooth muscle cells
title_short Endothelial cells are progenitors of cardiac pericytes and vascular smooth muscle cells
title_sort endothelial cells are progenitors of cardiac pericytes and vascular smooth muscle cells
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4990645/
https://www.ncbi.nlm.nih.gov/pubmed/27516371
http://dx.doi.org/10.1038/ncomms12422
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