Combined Detection of Serum IL-10, IL-17, and CXCL10 Predicts Acute Rejection Following Adult Liver Transplantation

Discovery of non-invasive diagnostic and predictive biomarkers for acute rejection in liver transplant patients would help to ensure the preservation of liver function in the graft, eventually contributing to improved graft and patient survival. We evaluated selected cytokines and chemokines in the...

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Autores principales: Kim, Nayoung, Yoon, Young-In, Yoo, Hyun Ju, Tak, Eunyoung, Ahn, Chul-Soo, Song, Gi-Won, Lee, Sung-Gyu, Hwang, Shin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Society for Molecular and Cellular Biology 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4990757/
https://www.ncbi.nlm.nih.gov/pubmed/27498551
http://dx.doi.org/10.14348/molcells.2016.0130
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author Kim, Nayoung
Yoon, Young-In
Yoo, Hyun Ju
Tak, Eunyoung
Ahn, Chul-Soo
Song, Gi-Won
Lee, Sung-Gyu
Hwang, Shin
author_facet Kim, Nayoung
Yoon, Young-In
Yoo, Hyun Ju
Tak, Eunyoung
Ahn, Chul-Soo
Song, Gi-Won
Lee, Sung-Gyu
Hwang, Shin
author_sort Kim, Nayoung
collection PubMed
description Discovery of non-invasive diagnostic and predictive biomarkers for acute rejection in liver transplant patients would help to ensure the preservation of liver function in the graft, eventually contributing to improved graft and patient survival. We evaluated selected cytokines and chemokines in the sera from liver transplant patients as potential biomarkers for acute rejection, and found that the combined detection of IL-10, IL-17, and CXCL10 at 1-2 weeks post-operation could predict acute rejection following adult liver transplantation with 97% specificity and 94% sensitivity.
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spelling pubmed-49907572016-09-01 Combined Detection of Serum IL-10, IL-17, and CXCL10 Predicts Acute Rejection Following Adult Liver Transplantation Kim, Nayoung Yoon, Young-In Yoo, Hyun Ju Tak, Eunyoung Ahn, Chul-Soo Song, Gi-Won Lee, Sung-Gyu Hwang, Shin Mol Cells Article Discovery of non-invasive diagnostic and predictive biomarkers for acute rejection in liver transplant patients would help to ensure the preservation of liver function in the graft, eventually contributing to improved graft and patient survival. We evaluated selected cytokines and chemokines in the sera from liver transplant patients as potential biomarkers for acute rejection, and found that the combined detection of IL-10, IL-17, and CXCL10 at 1-2 weeks post-operation could predict acute rejection following adult liver transplantation with 97% specificity and 94% sensitivity. Korean Society for Molecular and Cellular Biology 2016-08-31 2016-08-05 /pmc/articles/PMC4990757/ /pubmed/27498551 http://dx.doi.org/10.14348/molcells.2016.0130 Text en © The Korean Society for Molecular and Cellular Biology. All rights reserved. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/3.0/.
spellingShingle Article
Kim, Nayoung
Yoon, Young-In
Yoo, Hyun Ju
Tak, Eunyoung
Ahn, Chul-Soo
Song, Gi-Won
Lee, Sung-Gyu
Hwang, Shin
Combined Detection of Serum IL-10, IL-17, and CXCL10 Predicts Acute Rejection Following Adult Liver Transplantation
title Combined Detection of Serum IL-10, IL-17, and CXCL10 Predicts Acute Rejection Following Adult Liver Transplantation
title_full Combined Detection of Serum IL-10, IL-17, and CXCL10 Predicts Acute Rejection Following Adult Liver Transplantation
title_fullStr Combined Detection of Serum IL-10, IL-17, and CXCL10 Predicts Acute Rejection Following Adult Liver Transplantation
title_full_unstemmed Combined Detection of Serum IL-10, IL-17, and CXCL10 Predicts Acute Rejection Following Adult Liver Transplantation
title_short Combined Detection of Serum IL-10, IL-17, and CXCL10 Predicts Acute Rejection Following Adult Liver Transplantation
title_sort combined detection of serum il-10, il-17, and cxcl10 predicts acute rejection following adult liver transplantation
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4990757/
https://www.ncbi.nlm.nih.gov/pubmed/27498551
http://dx.doi.org/10.14348/molcells.2016.0130
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