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Immediate effects of cigar smoking on respiratory mechanics and exhaled biomarkers; differences between young smokers with mild asthma and otherwise healthy young smokers

BACKGROUND: We aimed to investigate the immediate respiratory effects of cigar smoking(CS), among young smokers with and without mild asthma. MATERIALS AND METHODS: Forty-seven young smokers (18–31years old, 29 males, average pack-years = 3.6 ± 2.8) were enrolled. Twenty-two were mild asthmatics(MA-...

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Autores principales: Lappas, Andreas S., Konstantinidi, Efstathia M., Tzortzi, Anna S., Tzavara, Chara K., Behrakis, Panagiotis K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4990845/
https://www.ncbi.nlm.nih.gov/pubmed/27547175
http://dx.doi.org/10.1186/s12971-016-0095-6
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author Lappas, Andreas S.
Konstantinidi, Efstathia M.
Tzortzi, Anna S.
Tzavara, Chara K.
Behrakis, Panagiotis K.
author_facet Lappas, Andreas S.
Konstantinidi, Efstathia M.
Tzortzi, Anna S.
Tzavara, Chara K.
Behrakis, Panagiotis K.
author_sort Lappas, Andreas S.
collection PubMed
description BACKGROUND: We aimed to investigate the immediate respiratory effects of cigar smoking(CS), among young smokers with and without mild asthma. MATERIALS AND METHODS: Forty-seven young smokers (18–31years old, 29 males, average pack-years = 3.6 ± 2.8) were enrolled. Twenty-two were mild asthmatics(MA-subgroup) and the remaining 25 were otherwise healthy smokers(HS-subgroup). Exhaled carbon monoxide(eCO), multi-frequency respiratory system impedance(Z), resistance(R), reactance(X), frequency-dependence of resistance(fdr = R5Hz - R20Hz), resonant frequency(f(res)), reactance area(AX) and exhaled nitric oxide(FENO) were measured at the aforementioned sequence, before and immediately after 30 min of CS, or equal session in the smoking area while using a sham cigar(control group). Chi-square, student’s t-tests, mixed linear models and Pearson correlation tests were used for the statistical analysis; level of significance was defined as p < 0.05. RESULTS: Immediately after CS, Z5Hz, R5Hz, R10Hz, R20Hz and eCO increased significantly in both subgroups(MA and HS). A greater increase was found for R20 in HS-subgroup. Fdr, f(res) and AX increased in MA, while decreased in HS. On the contrary, X10 decreased in MA and increased in HS, while X20 showed a greater decrease in MA. Changes in fdr, f(res) and AX were significantly correlated in both subgroups. No significant FENO alterations were detected in both subgroups. CONCLUSION: CS has immediate effects on pulmonary function. Mild asthma predisposes to higher increase of peripheral resistance(increased fdr). In otherwise healthy smokers, central resistance(R20Hz) is more affected. FENO levels are not significantly affected by CS.
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spelling pubmed-49908452016-08-20 Immediate effects of cigar smoking on respiratory mechanics and exhaled biomarkers; differences between young smokers with mild asthma and otherwise healthy young smokers Lappas, Andreas S. Konstantinidi, Efstathia M. Tzortzi, Anna S. Tzavara, Chara K. Behrakis, Panagiotis K. Tob Induc Dis Research BACKGROUND: We aimed to investigate the immediate respiratory effects of cigar smoking(CS), among young smokers with and without mild asthma. MATERIALS AND METHODS: Forty-seven young smokers (18–31years old, 29 males, average pack-years = 3.6 ± 2.8) were enrolled. Twenty-two were mild asthmatics(MA-subgroup) and the remaining 25 were otherwise healthy smokers(HS-subgroup). Exhaled carbon monoxide(eCO), multi-frequency respiratory system impedance(Z), resistance(R), reactance(X), frequency-dependence of resistance(fdr = R5Hz - R20Hz), resonant frequency(f(res)), reactance area(AX) and exhaled nitric oxide(FENO) were measured at the aforementioned sequence, before and immediately after 30 min of CS, or equal session in the smoking area while using a sham cigar(control group). Chi-square, student’s t-tests, mixed linear models and Pearson correlation tests were used for the statistical analysis; level of significance was defined as p < 0.05. RESULTS: Immediately after CS, Z5Hz, R5Hz, R10Hz, R20Hz and eCO increased significantly in both subgroups(MA and HS). A greater increase was found for R20 in HS-subgroup. Fdr, f(res) and AX increased in MA, while decreased in HS. On the contrary, X10 decreased in MA and increased in HS, while X20 showed a greater decrease in MA. Changes in fdr, f(res) and AX were significantly correlated in both subgroups. No significant FENO alterations were detected in both subgroups. CONCLUSION: CS has immediate effects on pulmonary function. Mild asthma predisposes to higher increase of peripheral resistance(increased fdr). In otherwise healthy smokers, central resistance(R20Hz) is more affected. FENO levels are not significantly affected by CS. BioMed Central 2016-08-18 /pmc/articles/PMC4990845/ /pubmed/27547175 http://dx.doi.org/10.1186/s12971-016-0095-6 Text en © The Author(s). 2016 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research
Lappas, Andreas S.
Konstantinidi, Efstathia M.
Tzortzi, Anna S.
Tzavara, Chara K.
Behrakis, Panagiotis K.
Immediate effects of cigar smoking on respiratory mechanics and exhaled biomarkers; differences between young smokers with mild asthma and otherwise healthy young smokers
title Immediate effects of cigar smoking on respiratory mechanics and exhaled biomarkers; differences between young smokers with mild asthma and otherwise healthy young smokers
title_full Immediate effects of cigar smoking on respiratory mechanics and exhaled biomarkers; differences between young smokers with mild asthma and otherwise healthy young smokers
title_fullStr Immediate effects of cigar smoking on respiratory mechanics and exhaled biomarkers; differences between young smokers with mild asthma and otherwise healthy young smokers
title_full_unstemmed Immediate effects of cigar smoking on respiratory mechanics and exhaled biomarkers; differences between young smokers with mild asthma and otherwise healthy young smokers
title_short Immediate effects of cigar smoking on respiratory mechanics and exhaled biomarkers; differences between young smokers with mild asthma and otherwise healthy young smokers
title_sort immediate effects of cigar smoking on respiratory mechanics and exhaled biomarkers; differences between young smokers with mild asthma and otherwise healthy young smokers
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4990845/
https://www.ncbi.nlm.nih.gov/pubmed/27547175
http://dx.doi.org/10.1186/s12971-016-0095-6
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