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Creation of an engineered APC system to explore and optimize the presentation of immunodominant peptides of major allergens

We have generated engineered APC to present immunodominant peptides derived from the major aero-allergens of birch and mugwort pollen, Bet v 1(142–153) and Art v 1(25–36), respectively. Jurkat-based T cell reporter lines expressing the cognate allergen-specific T cell receptors were used to read out...

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Detalles Bibliográficos
Autores principales:	Rosskopf, Sandra, Jutz, Sabrina, Neunkirchner, Alina, Candia, Martín R., Jahn-Schmid, Beatrice, Bohle, Barbara, Pickl, Winfried F., Steinberger, Peter
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4990899/ https://www.ncbi.nlm.nih.gov/pubmed/27539532 http://dx.doi.org/10.1038/srep31580

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