A regulatory loop between miR-132 and miR-125b involved in gonadotrope cells desensitization to GnRH

The GnRH neurohormone is the main activator of the pituitary gonadotropins, LH and FSH. Here we investigated the contribution of microRNAs in mediating GnRH activation. We first established that miR-125b targets several actors of Gαq/11 signalling pathway, without altering Gαs pathway. We then showe...

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Detalles Bibliográficos
Autores principales: Lannes, Jérôme, L’hôte, David, Fernandez-Vega, Ambra, Garrel, Ghislaine, Laverrière, Jean-Noël, Joëlle-Cohen-Tannoudji, J -C -T, Quérat, Bruno
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4990909/
https://www.ncbi.nlm.nih.gov/pubmed/27539363
http://dx.doi.org/10.1038/srep31563

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4990909/
https://www.ncbi.nlm.nih.gov/pubmed/27539363
http://dx.doi.org/10.1038/srep31563

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