Cargando…

Defective recognition of LC3B by mutant SQSTM1/p62 implicates impairment of autophagy as a pathogenic mechanism in ALS-FTLD

Growing evidence implicates impairment of autophagy as a candidate pathogenic mechanism in the spectrum of neurodegenerative disorders which includes amyotrophic lateral sclerosis and frontotemporal lobar degeneration (ALS-FTLD). SQSTM1, which encodes the autophagy receptor SQSTM1/p62, is geneticall...

Descripción completa

Detalles Bibliográficos
Autores principales:	Goode, Alice, Butler, Kevin, Long, Jed, Cavey, James, Scott, Daniel, Shaw, Barry, Sollenberger, Jill, Gell, Christopher, Johansen, Terje, Oldham, Neil J., Searle, Mark S., Layfield, Robert
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Taylor & Francis 2016
Materias:	Basic Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4990988/ https://www.ncbi.nlm.nih.gov/pubmed/27158844 http://dx.doi.org/10.1080/15548627.2016.1170257

Ejemplares similares

ALS-FTLD associated mutations of SQSTM1 impact on Keap1-Nrf2 signalling
por: Goode, Alice, et al.
Publicado: (2016)

An ALS-associated variant of the autophagy receptor SQSTM1/p62 reprograms binding selectivity toward the autophagy-related hATG8 proteins
por: Brennan, Andrew, et al.
Publicado: (2021)

The higher-order molecular organization of p62/SQSTM1
por: Johansen, Terje, et al.
Publicado: (2015)

SQSTM1/p62 mediates crosstalk between autophagy and the UPS in DNA repair
por: Hewitt, Graeme, et al.
Publicado: (2016)

p62/SQSTM1 but not LC3 is accumulated in sarcopenic muscle of mice
por: Sakuma, Kunihiro, et al.
Publicado: (2015)

Clinical significance of SQSTM1/P62 and nuclear factor-κB expression in pancreatic carcinoma
por: Zhang, Zhao-Yang, et al.
Publicado: (2020)

Paget disease of bone-associated UBA domain mutations of SQSTM1 exert distinct effects on protein structure and function
por: Goode, Alice, et al.
Publicado: (2014)

HSF1 stress response pathway regulates autophagy receptor SQSTM1/p62-associated proteostasis
por: Watanabe, Yoshihisa, et al.
Publicado: (2016)

Upregulation of SQSTM1/p62 contributes to nickel-induced malignant transformation of human bronchial epithelial cells
por: Huang, Haishan, et al.
Publicado: (2016)

SPBP Is a Sulforaphane Induced Transcriptional Coactivator of NRF2 Regulating Expression of the Autophagy Receptor p62/SQSTM1
por: Darvekar, Sagar Ramesh, et al.
Publicado: (2014)

Structural basis of p62/SQSTM1 helical filaments and their role in cellular cargo uptake
por: Jakobi, Arjen J., et al.
Publicado: (2020)

p62/SQSTM1 forms protein aggregates degraded by autophagy and has a protective effect on huntingtin-induced cell death
por: Bjørkøy, Geir, et al.
Publicado: (2005)

Expression of the autophagy substrate SQSTM1/p62 is restored during prolonged starvation depending on transcriptional upregulation and autophagy-derived amino acids
por: Sahani, Mayurbhai Himatbhai, et al.
Publicado: (2014)

Prognostic significance of p62/SQSTM1 subcellular localization and LC3B in oral squamous cell carcinoma
por: Liu, J-L, et al.
Publicado: (2014)

AMBRA1 is able to induce mitophagy via LC3 binding, regardless of PARKIN and p62/SQSTM1
por: Strappazzon, F, et al.
Publicado: (2015)

Aichi virus 3C protease modulates LC3- and SQSTM1/p62-involved antiviral response
por: Kung, Ming-Hsiang, et al.
Publicado: (2020)

N-3 PUFAs induce inflammatory tolerance by formation of KEAP1-containing SQSTM1/p62-bodies and activation of NFE2L2
por: Mildenberger, Jennifer, et al.
Publicado: (2017)

Association of p62/SQSTM1 Excess and Oral Carcinogenesis
por: Inui, Takuma, et al.
Publicado: (2013)

ZZ-dependent regulation of p62/SQSTM1 in autophagy
por: Zhang, Yi, et al.
Publicado: (2018)

p62/Sqstm1 rescue in muscle retards the progression of steatohepatitis in p62/Sqstm1-null mice fed a high-fat diet
por: Miura, Ikuru, et al.
Publicado: (2022)

Prognostic value of the autophagy markers LC3 and p62/SQSTM1 in early-stage non-small cell lung cancer
por: Schläfli, Anna M., et al.
Publicado: (2016)

FTLD Patient–Derived Fibroblasts Show Defective Mitochondrial Function and Accumulation of p62
por: Leskelä, Stina, et al.
Publicado: (2021)

NUP62 localizes to ALS/FTLD pathological assemblies and contributes to TDP-43 insolubility
por: Gleixner, Amanda M., et al.
Publicado: (2022)

The adaptor protein p62/SQSTM1 in osteoclast signaling pathways
por: McManus, Stephen, et al.
Publicado: (2012)

p62/SQSTM1 synergizes with autophagy for tumor growth in vivo
por: Wei, Huijun, et al.
Publicado: (2014)

p62/SQSTM1: ‘Jack of all trades’ in health and cancer
por: Sánchez‐Martín, Pablo, et al.
Publicado: (2018)

SQSTM-1/p62 potentiates HTLV-1 Tax-mediated NF-κB activation through its ubiquitin binding function
por: Schwob, Aurélien, et al.
Publicado: (2019)

Identification of p62/SQSTM1 as a component of non-canonical Wnt VANGL2–JNK signalling in breast cancer
por: Puvirajesinghe, Tania M., et al.
Publicado: (2016)

Preconditioning Involves Selective Mitophagy Mediated by Parkin and p62/SQSTM1
por: Huang, Chengqun, et al.
Publicado: (2011)

p62/SQSTM1 cooperates with Parkin for perinuclear clustering of depolarized mitochondria
por: Okatsu, Kei, et al.
Publicado: (2010)

Tissue Specific Induction of p62/Sqstm1 by Farnesoid X Receptor
por: Williams, Jessica A., et al.
Publicado: (2012)

SQSTM1/p62 Interacts with HDAC6 and Regulates Deacetylase Activity
por: Yan, Jin, et al.
Publicado: (2013)

p62/SQSTM1 interacts with vimentin to enhance breast cancer metastasis
por: Li, Si-Si, et al.
Publicado: (2017)

SQSTM1/p62-Directed Metabolic Reprogramming Is Essential for Normal Neurodifferentiation
por: Calvo-Garrido, Javier, et al.
Publicado: (2019)

Genetic and Molecular Evaluation of SQSTM1/p62 on the Neuropathologies of Alzheimer’s Disease
por: Dong, Wei, et al.
Publicado: (2022)

Ubiquitin ligase SYVN1/HRD1 facilitates degradation of the SERPINA1 Z variant/α-1-antitrypsin Z variant via SQSTM1/p62-dependent selective autophagy
por: Feng, Lijie, et al.
Publicado: (2017)

Phase-separated protein droplets of amyotrophic lateral sclerosis-associated p62/SQSTM1 mutants show reduced inner fluidity
por: Faruk, Mohammad Omar, et al.
Publicado: (2021)

The autophagy receptor SQSTM1/p62 mediates anti-inflammatory actions of the selective NR3C1/glucocorticoid receptor modulator compound A (CpdA) in macrophages
por: Mylka, Viacheslav, et al.
Publicado: (2018)

Developmental regulation of MURF ubiquitin ligases and autophagy proteins nbr1, p62/SQSTM1 and LC3 during cardiac myofibril assembly and turnover
por: Perera, Sue, et al.
Publicado: (2011)

Alteration of p62/SQSTM1 Expression Is Uncommon in Gastrointestinal and Prostate Cancer Tissues
por: Je, Eun Mi, et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_fmc3rbj9fcnfds2rkl5fjugalo