A case of primary spinal atypical teratoid/rhabdoid tumor in a 5-year-old child

Atypical teratoid/rhabdoid tumor (AT/RT) is a rare central nervous system neoplasm affecting children, and isolated primary spinal involvement is extremely rare. Authors describe a case of spinal AT/RT in a 5-year-old male child presenting with rapidly progressing quadriparesis diagnosed and managed...

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Autores principales: Mankotia, Dipanker Singh, Tandon, Vivek, Sharma, Bhawani Shankar, Rajeshwari, Madhu, Sharma, Mehar Chand
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2016
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4991152/
https://www.ncbi.nlm.nih.gov/pubmed/27606020
http://dx.doi.org/10.4103/1817-1745.187634
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author Mankotia, Dipanker Singh
Tandon, Vivek
Sharma, Bhawani Shankar
Rajeshwari, Madhu
Sharma, Mehar Chand
author_facet Mankotia, Dipanker Singh
Tandon, Vivek
Sharma, Bhawani Shankar
Rajeshwari, Madhu
Sharma, Mehar Chand
author_sort Mankotia, Dipanker Singh
collection PubMed
description Atypical teratoid/rhabdoid tumor (AT/RT) is a rare central nervous system neoplasm affecting children, and isolated primary spinal involvement is extremely rare. Authors describe a case of spinal AT/RT in a 5-year-old male child presenting with rapidly progressing quadriparesis diagnosed and managed surgically and medically. Biopsy revealed large, rhabdoid cells with prominent nucleoli in nest and immunohistochemistry further showed loss of integrase integrator 1 expression considered to be gold standard for diagnosis. AT/RT has extremely poor prognosis with median survival being 6 months.
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spelling pubmed-49911522016-09-07 A case of primary spinal atypical teratoid/rhabdoid tumor in a 5-year-old child Mankotia, Dipanker Singh Tandon, Vivek Sharma, Bhawani Shankar Rajeshwari, Madhu Sharma, Mehar Chand J Pediatr Neurosci Case Report Atypical teratoid/rhabdoid tumor (AT/RT) is a rare central nervous system neoplasm affecting children, and isolated primary spinal involvement is extremely rare. Authors describe a case of spinal AT/RT in a 5-year-old male child presenting with rapidly progressing quadriparesis diagnosed and managed surgically and medically. Biopsy revealed large, rhabdoid cells with prominent nucleoli in nest and immunohistochemistry further showed loss of integrase integrator 1 expression considered to be gold standard for diagnosis. AT/RT has extremely poor prognosis with median survival being 6 months. Medknow Publications & Media Pvt Ltd 2016 /pmc/articles/PMC4991152/ /pubmed/27606020 http://dx.doi.org/10.4103/1817-1745.187634 Text en Copyright: © Journal of Pediatric Neurosciences http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms.
spellingShingle Case Report
Mankotia, Dipanker Singh
Tandon, Vivek
Sharma, Bhawani Shankar
Rajeshwari, Madhu
Sharma, Mehar Chand
A case of primary spinal atypical teratoid/rhabdoid tumor in a 5-year-old child
title A case of primary spinal atypical teratoid/rhabdoid tumor in a 5-year-old child
title_full A case of primary spinal atypical teratoid/rhabdoid tumor in a 5-year-old child
title_fullStr A case of primary spinal atypical teratoid/rhabdoid tumor in a 5-year-old child
title_full_unstemmed A case of primary spinal atypical teratoid/rhabdoid tumor in a 5-year-old child
title_short A case of primary spinal atypical teratoid/rhabdoid tumor in a 5-year-old child
title_sort case of primary spinal atypical teratoid/rhabdoid tumor in a 5-year-old child
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4991152/
https://www.ncbi.nlm.nih.gov/pubmed/27606020
http://dx.doi.org/10.4103/1817-1745.187634
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