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Transient Elastography in Clinical Detection of Liver Cirrhosis: A Systematic Review and Meta-analysis

BACKGROUND/AIMS: Transient elastography is a noninvasive method for measuring liver fibrosis. This meta-analysis assesses the diagnostic performance of transient elastography of detecting liver cirrhosis in patients with liver disease. PATIENTS AND METHODS: We searched MEDLINE, Cochrane, EMBASE data...

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Autores principales: Geng, Xiao-Xia, Huang, Ren-Gang, Lin, Jian-Mei, Jiang, Nan, Yang, Xing-Xiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4991200/
https://www.ncbi.nlm.nih.gov/pubmed/27488324
http://dx.doi.org/10.4103/1319-3767.187603
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author Geng, Xiao-Xia
Huang, Ren-Gang
Lin, Jian-Mei
Jiang, Nan
Yang, Xing-Xiang
author_facet Geng, Xiao-Xia
Huang, Ren-Gang
Lin, Jian-Mei
Jiang, Nan
Yang, Xing-Xiang
author_sort Geng, Xiao-Xia
collection PubMed
description BACKGROUND/AIMS: Transient elastography is a noninvasive method for measuring liver fibrosis. This meta-analysis assesses the diagnostic performance of transient elastography of detecting liver cirrhosis in patients with liver disease. PATIENTS AND METHODS: We searched MEDLINE, Cochrane, EMBASE databases until Jan 31, 2015, using the following search terms: elastography and liver cirrhosis. Included studies assessed patients with a diagnosis of liver cirrhosis, with an index test of transient elastography, and with the reference standard being a histopathological exam by liver biopsy. Sensitivity analysis and assessment of risk of bias and publication bias were performed. RESULTS: Fifty-seven studies were included in the meta-analysis with a total of 10,504 patients. The pooled estimate for the sensitivity of transient elastography for detecting liver fibrosis was 81% and the specificity was 88%. The imputed diagnostic odds ratio (DOR) was 26.08 and the area under the receiver-operating characteristic (AUROC) curve was 0.931. CONCLUSION: Our findings indicate that transient elastography shows good sensitivity, specificity and a high accuracy for detecting liver cirrhosis. Transient elastography can be used as an additional method for the clinical diagnosis of liver fibrosis and cirrhosis.
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spelling pubmed-49912002016-09-07 Transient Elastography in Clinical Detection of Liver Cirrhosis: A Systematic Review and Meta-analysis Geng, Xiao-Xia Huang, Ren-Gang Lin, Jian-Mei Jiang, Nan Yang, Xing-Xiang Saudi J Gastroenterol Original Article BACKGROUND/AIMS: Transient elastography is a noninvasive method for measuring liver fibrosis. This meta-analysis assesses the diagnostic performance of transient elastography of detecting liver cirrhosis in patients with liver disease. PATIENTS AND METHODS: We searched MEDLINE, Cochrane, EMBASE databases until Jan 31, 2015, using the following search terms: elastography and liver cirrhosis. Included studies assessed patients with a diagnosis of liver cirrhosis, with an index test of transient elastography, and with the reference standard being a histopathological exam by liver biopsy. Sensitivity analysis and assessment of risk of bias and publication bias were performed. RESULTS: Fifty-seven studies were included in the meta-analysis with a total of 10,504 patients. The pooled estimate for the sensitivity of transient elastography for detecting liver fibrosis was 81% and the specificity was 88%. The imputed diagnostic odds ratio (DOR) was 26.08 and the area under the receiver-operating characteristic (AUROC) curve was 0.931. CONCLUSION: Our findings indicate that transient elastography shows good sensitivity, specificity and a high accuracy for detecting liver cirrhosis. Transient elastography can be used as an additional method for the clinical diagnosis of liver fibrosis and cirrhosis. Medknow Publications & Media Pvt Ltd 2016 /pmc/articles/PMC4991200/ /pubmed/27488324 http://dx.doi.org/10.4103/1319-3767.187603 Text en Copyright: © Saudi Journal of Gastroenterology http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms.
spellingShingle Original Article
Geng, Xiao-Xia
Huang, Ren-Gang
Lin, Jian-Mei
Jiang, Nan
Yang, Xing-Xiang
Transient Elastography in Clinical Detection of Liver Cirrhosis: A Systematic Review and Meta-analysis
title Transient Elastography in Clinical Detection of Liver Cirrhosis: A Systematic Review and Meta-analysis
title_full Transient Elastography in Clinical Detection of Liver Cirrhosis: A Systematic Review and Meta-analysis
title_fullStr Transient Elastography in Clinical Detection of Liver Cirrhosis: A Systematic Review and Meta-analysis
title_full_unstemmed Transient Elastography in Clinical Detection of Liver Cirrhosis: A Systematic Review and Meta-analysis
title_short Transient Elastography in Clinical Detection of Liver Cirrhosis: A Systematic Review and Meta-analysis
title_sort transient elastography in clinical detection of liver cirrhosis: a systematic review and meta-analysis
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4991200/
https://www.ncbi.nlm.nih.gov/pubmed/27488324
http://dx.doi.org/10.4103/1319-3767.187603
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