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Transient Elastography in Clinical Detection of Liver Cirrhosis: A Systematic Review and Meta-analysis
BACKGROUND/AIMS: Transient elastography is a noninvasive method for measuring liver fibrosis. This meta-analysis assesses the diagnostic performance of transient elastography of detecting liver cirrhosis in patients with liver disease. PATIENTS AND METHODS: We searched MEDLINE, Cochrane, EMBASE data...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Medknow Publications & Media Pvt Ltd
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4991200/ https://www.ncbi.nlm.nih.gov/pubmed/27488324 http://dx.doi.org/10.4103/1319-3767.187603 |
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author | Geng, Xiao-Xia Huang, Ren-Gang Lin, Jian-Mei Jiang, Nan Yang, Xing-Xiang |
author_facet | Geng, Xiao-Xia Huang, Ren-Gang Lin, Jian-Mei Jiang, Nan Yang, Xing-Xiang |
author_sort | Geng, Xiao-Xia |
collection | PubMed |
description | BACKGROUND/AIMS: Transient elastography is a noninvasive method for measuring liver fibrosis. This meta-analysis assesses the diagnostic performance of transient elastography of detecting liver cirrhosis in patients with liver disease. PATIENTS AND METHODS: We searched MEDLINE, Cochrane, EMBASE databases until Jan 31, 2015, using the following search terms: elastography and liver cirrhosis. Included studies assessed patients with a diagnosis of liver cirrhosis, with an index test of transient elastography, and with the reference standard being a histopathological exam by liver biopsy. Sensitivity analysis and assessment of risk of bias and publication bias were performed. RESULTS: Fifty-seven studies were included in the meta-analysis with a total of 10,504 patients. The pooled estimate for the sensitivity of transient elastography for detecting liver fibrosis was 81% and the specificity was 88%. The imputed diagnostic odds ratio (DOR) was 26.08 and the area under the receiver-operating characteristic (AUROC) curve was 0.931. CONCLUSION: Our findings indicate that transient elastography shows good sensitivity, specificity and a high accuracy for detecting liver cirrhosis. Transient elastography can be used as an additional method for the clinical diagnosis of liver fibrosis and cirrhosis. |
format | Online Article Text |
id | pubmed-4991200 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Medknow Publications & Media Pvt Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-49912002016-09-07 Transient Elastography in Clinical Detection of Liver Cirrhosis: A Systematic Review and Meta-analysis Geng, Xiao-Xia Huang, Ren-Gang Lin, Jian-Mei Jiang, Nan Yang, Xing-Xiang Saudi J Gastroenterol Original Article BACKGROUND/AIMS: Transient elastography is a noninvasive method for measuring liver fibrosis. This meta-analysis assesses the diagnostic performance of transient elastography of detecting liver cirrhosis in patients with liver disease. PATIENTS AND METHODS: We searched MEDLINE, Cochrane, EMBASE databases until Jan 31, 2015, using the following search terms: elastography and liver cirrhosis. Included studies assessed patients with a diagnosis of liver cirrhosis, with an index test of transient elastography, and with the reference standard being a histopathological exam by liver biopsy. Sensitivity analysis and assessment of risk of bias and publication bias were performed. RESULTS: Fifty-seven studies were included in the meta-analysis with a total of 10,504 patients. The pooled estimate for the sensitivity of transient elastography for detecting liver fibrosis was 81% and the specificity was 88%. The imputed diagnostic odds ratio (DOR) was 26.08 and the area under the receiver-operating characteristic (AUROC) curve was 0.931. CONCLUSION: Our findings indicate that transient elastography shows good sensitivity, specificity and a high accuracy for detecting liver cirrhosis. Transient elastography can be used as an additional method for the clinical diagnosis of liver fibrosis and cirrhosis. Medknow Publications & Media Pvt Ltd 2016 /pmc/articles/PMC4991200/ /pubmed/27488324 http://dx.doi.org/10.4103/1319-3767.187603 Text en Copyright: © Saudi Journal of Gastroenterology http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms. |
spellingShingle | Original Article Geng, Xiao-Xia Huang, Ren-Gang Lin, Jian-Mei Jiang, Nan Yang, Xing-Xiang Transient Elastography in Clinical Detection of Liver Cirrhosis: A Systematic Review and Meta-analysis |
title | Transient Elastography in Clinical Detection of Liver Cirrhosis: A Systematic Review and Meta-analysis |
title_full | Transient Elastography in Clinical Detection of Liver Cirrhosis: A Systematic Review and Meta-analysis |
title_fullStr | Transient Elastography in Clinical Detection of Liver Cirrhosis: A Systematic Review and Meta-analysis |
title_full_unstemmed | Transient Elastography in Clinical Detection of Liver Cirrhosis: A Systematic Review and Meta-analysis |
title_short | Transient Elastography in Clinical Detection of Liver Cirrhosis: A Systematic Review and Meta-analysis |
title_sort | transient elastography in clinical detection of liver cirrhosis: a systematic review and meta-analysis |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4991200/ https://www.ncbi.nlm.nih.gov/pubmed/27488324 http://dx.doi.org/10.4103/1319-3767.187603 |
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