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New Combined Parameter of Liver and Splenic Stiffness as Determined by Elastography in Healthy Volunteers

BACKGROUND: The diagnosis of chronic liver disease (CLD) leading to fibrosis, cirrhosis, and portal hypertension had witnessed dramatic changes after the introduction of noninvasive figure accessible tools over the past few years. Imaging techniques that are based on evaluation of the liver stiffnes...

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Autores principales: Kassym, Laura, Nounou, Mohammed A., Zhumadilova, Zauresh, Dajani, Asad I., Barkibayeva, Nurgul, Myssayev, Ayan, Rakhypbekov, Tolebay, Abuhammour, Adnan M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4991204/
https://www.ncbi.nlm.nih.gov/pubmed/27488328
http://dx.doi.org/10.4103/1319-3767.187607
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author Kassym, Laura
Nounou, Mohammed A.
Zhumadilova, Zauresh
Dajani, Asad I.
Barkibayeva, Nurgul
Myssayev, Ayan
Rakhypbekov, Tolebay
Abuhammour, Adnan M.
author_facet Kassym, Laura
Nounou, Mohammed A.
Zhumadilova, Zauresh
Dajani, Asad I.
Barkibayeva, Nurgul
Myssayev, Ayan
Rakhypbekov, Tolebay
Abuhammour, Adnan M.
author_sort Kassym, Laura
collection PubMed
description BACKGROUND: The diagnosis of chronic liver disease (CLD) leading to fibrosis, cirrhosis, and portal hypertension had witnessed dramatic changes after the introduction of noninvasive figure accessible tools over the past few years. Imaging techniques that are based on evaluation of the liver stiffness was particularly useful in this respect. Acoustic radiation force impulse (ARFI) emerged as an interesting figure tool with reliable repute and high precision. AIMS: To evaluate liver stiffness measurement (LSM) and splenic stiffness measurement (SSM) in healthy volunteers as concluded by the ARFI technique and to out a numeric calculated ratio that may reflect their correlation in the otherwise healthy liver. PATIENTS AND METHODS: A ratio (splenic stiffness/liver stiffness in kPa) was determined in 207 consenting healthy subjects and was investigated with respect to age, gender, ethnic origin, body mass index (BMI), liver and spleen sizes healthy volunteers, alanine aminotransferase (ALT), aspartate aminotransferase (AST), platelet count (PLT), APRI, and FIB-4 scores. RESULTS: Data from this work led to computing an index of 4.72 (3.42–7.33) in healthy persons on an average. Females had a higher index than males 6.37 vs 4.92, P=0.002. There was not any significant difference of the ratio in different age groups; ethnic origins; any correlation between SSM/LSM ratio and BMI; liver and spleen sizes; or ALT, AST, PLT, APRI, and FIB-4 scores. CONCLUSIONS: A quantifiable numeric relationship between splenic and liver stiffness in the healthy subjects could be computed to a parameter expressed as SSM/LSM ratio. We believe that this ratio can be a useful reference tool for further researches in CLD.
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spelling pubmed-49912042016-09-07 New Combined Parameter of Liver and Splenic Stiffness as Determined by Elastography in Healthy Volunteers Kassym, Laura Nounou, Mohammed A. Zhumadilova, Zauresh Dajani, Asad I. Barkibayeva, Nurgul Myssayev, Ayan Rakhypbekov, Tolebay Abuhammour, Adnan M. Saudi J Gastroenterol Original Article BACKGROUND: The diagnosis of chronic liver disease (CLD) leading to fibrosis, cirrhosis, and portal hypertension had witnessed dramatic changes after the introduction of noninvasive figure accessible tools over the past few years. Imaging techniques that are based on evaluation of the liver stiffness was particularly useful in this respect. Acoustic radiation force impulse (ARFI) emerged as an interesting figure tool with reliable repute and high precision. AIMS: To evaluate liver stiffness measurement (LSM) and splenic stiffness measurement (SSM) in healthy volunteers as concluded by the ARFI technique and to out a numeric calculated ratio that may reflect their correlation in the otherwise healthy liver. PATIENTS AND METHODS: A ratio (splenic stiffness/liver stiffness in kPa) was determined in 207 consenting healthy subjects and was investigated with respect to age, gender, ethnic origin, body mass index (BMI), liver and spleen sizes healthy volunteers, alanine aminotransferase (ALT), aspartate aminotransferase (AST), platelet count (PLT), APRI, and FIB-4 scores. RESULTS: Data from this work led to computing an index of 4.72 (3.42–7.33) in healthy persons on an average. Females had a higher index than males 6.37 vs 4.92, P=0.002. There was not any significant difference of the ratio in different age groups; ethnic origins; any correlation between SSM/LSM ratio and BMI; liver and spleen sizes; or ALT, AST, PLT, APRI, and FIB-4 scores. CONCLUSIONS: A quantifiable numeric relationship between splenic and liver stiffness in the healthy subjects could be computed to a parameter expressed as SSM/LSM ratio. We believe that this ratio can be a useful reference tool for further researches in CLD. Medknow Publications & Media Pvt Ltd 2016 /pmc/articles/PMC4991204/ /pubmed/27488328 http://dx.doi.org/10.4103/1319-3767.187607 Text en Copyright: © Saudi Journal of Gastroenterology http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms.
spellingShingle Original Article
Kassym, Laura
Nounou, Mohammed A.
Zhumadilova, Zauresh
Dajani, Asad I.
Barkibayeva, Nurgul
Myssayev, Ayan
Rakhypbekov, Tolebay
Abuhammour, Adnan M.
New Combined Parameter of Liver and Splenic Stiffness as Determined by Elastography in Healthy Volunteers
title New Combined Parameter of Liver and Splenic Stiffness as Determined by Elastography in Healthy Volunteers
title_full New Combined Parameter of Liver and Splenic Stiffness as Determined by Elastography in Healthy Volunteers
title_fullStr New Combined Parameter of Liver and Splenic Stiffness as Determined by Elastography in Healthy Volunteers
title_full_unstemmed New Combined Parameter of Liver and Splenic Stiffness as Determined by Elastography in Healthy Volunteers
title_short New Combined Parameter of Liver and Splenic Stiffness as Determined by Elastography in Healthy Volunteers
title_sort new combined parameter of liver and splenic stiffness as determined by elastography in healthy volunteers
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4991204/
https://www.ncbi.nlm.nih.gov/pubmed/27488328
http://dx.doi.org/10.4103/1319-3767.187607
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