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The nuclear lamina in health and disease
The nuclear lamina (NL) is a structural component of the nuclear envelope and makes extensive contacts with integral nuclear membrane proteins and chromatin. These interactions are critical for many cellular processes, such as nuclear positioning, perception of mechanical stimuli from the cell surfa...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Taylor & Francis
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4991244/ https://www.ncbi.nlm.nih.gov/pubmed/27158763 http://dx.doi.org/10.1080/19491034.2016.1183848 |
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author | Dobrzynska, Agnieszka Gonzalo, Susana Shanahan, Catherine Askjaer, Peter |
author_facet | Dobrzynska, Agnieszka Gonzalo, Susana Shanahan, Catherine Askjaer, Peter |
author_sort | Dobrzynska, Agnieszka |
collection | PubMed |
description | The nuclear lamina (NL) is a structural component of the nuclear envelope and makes extensive contacts with integral nuclear membrane proteins and chromatin. These interactions are critical for many cellular processes, such as nuclear positioning, perception of mechanical stimuli from the cell surface, nuclear stability, 3-dimensional organization of chromatin and regulation of chromatin-binding proteins, including transcription factors. The NL is present in all nucleated metazoan cells but its composition and interactome differ between tissues. Most likely, this contributes to the broad spectrum of disease manifestations in humans with mutations in NL-related genes, ranging from muscle dystrophies to neurological disorders, lipodystrophies and progeria syndromes. We review here exciting novel insight into NL function at the cellular level, in particular in chromatin organization and mechanosensation. We also present recent observations on the relation between the NL and metabolism and the special relevance of the NL in muscle tissues. Finally, we discuss new therapeutic approaches to treat NL-related diseases. |
format | Online Article Text |
id | pubmed-4991244 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Taylor & Francis |
record_format | MEDLINE/PubMed |
spelling | pubmed-49912442016-08-30 The nuclear lamina in health and disease Dobrzynska, Agnieszka Gonzalo, Susana Shanahan, Catherine Askjaer, Peter Nucleus Commentary The nuclear lamina (NL) is a structural component of the nuclear envelope and makes extensive contacts with integral nuclear membrane proteins and chromatin. These interactions are critical for many cellular processes, such as nuclear positioning, perception of mechanical stimuli from the cell surface, nuclear stability, 3-dimensional organization of chromatin and regulation of chromatin-binding proteins, including transcription factors. The NL is present in all nucleated metazoan cells but its composition and interactome differ between tissues. Most likely, this contributes to the broad spectrum of disease manifestations in humans with mutations in NL-related genes, ranging from muscle dystrophies to neurological disorders, lipodystrophies and progeria syndromes. We review here exciting novel insight into NL function at the cellular level, in particular in chromatin organization and mechanosensation. We also present recent observations on the relation between the NL and metabolism and the special relevance of the NL in muscle tissues. Finally, we discuss new therapeutic approaches to treat NL-related diseases. Taylor & Francis 2016-05-09 /pmc/articles/PMC4991244/ /pubmed/27158763 http://dx.doi.org/10.1080/19491034.2016.1183848 Text en © 2016 The Author(s). Published with license by Taylor & Francis Group, LLC http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The moral rights of the named author(s) have been asserted. |
spellingShingle | Commentary Dobrzynska, Agnieszka Gonzalo, Susana Shanahan, Catherine Askjaer, Peter The nuclear lamina in health and disease |
title | The nuclear lamina in health and disease |
title_full | The nuclear lamina in health and disease |
title_fullStr | The nuclear lamina in health and disease |
title_full_unstemmed | The nuclear lamina in health and disease |
title_short | The nuclear lamina in health and disease |
title_sort | nuclear lamina in health and disease |
topic | Commentary |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4991244/ https://www.ncbi.nlm.nih.gov/pubmed/27158763 http://dx.doi.org/10.1080/19491034.2016.1183848 |
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