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Evaluation of options for harvest of a recombinant E. Coli fermentation producing a domain antibody using ultra scale‐down techniques and pilot‐scale verification

Ultra scale‐down (USD) methods operating at the millilitre scale were used to characterise full‐scale processing of E. coli fermentation broths autolysed to different extents for release of a domain antibody. The focus was on the primary clarification stages involving continuous centrifugation follo...

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Detalles Bibliográficos
Autores principales:	Voulgaris, Ioannis, Chatel, Alex, Hoare, Mike, Finka, Gary, Uden, Mark
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2016
Materias:	Bioseparations and Downstream Processing
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4991298/ https://www.ncbi.nlm.nih.gov/pubmed/26698375 http://dx.doi.org/10.1002/btpr.2220

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