Potency of a human monoclonal antibody to diphtheria toxin relative to equine diphtheria anti-toxin in a guinea pig intoxication model

Prompt administration of anti-toxin reduces mortality following Corynebacterium diphtheriae infection. Current treatment relies upon equine diphtheria anti-toxin (DAT), with a 10% risk of serum sickness and rarely anaphylaxis. The global DAT supply is extremely limited; most manufacturers have cease...

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Detalles Bibliográficos
Autores principales: Smith, Heidi L., Cheslock, Peter, Leney, Mark, Barton, Bruce, Molrine, Deborah C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4991329/
https://www.ncbi.nlm.nih.gov/pubmed/27070129
http://dx.doi.org/10.1080/21505594.2016.1171436

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