The heterogeneity of store-operated calcium entry in melanoma

Calcium is a key regulator of many physiological processes that are perturbed in cancer, such as migration, proliferation and apoptosis. The proteins STIM and Orai mediate store-operated calcium entry (SOCE), the main pathway for calcium entry in non-excitable cells. Changes in the expression and fu...

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Autores principales: Hooper, Robert, Zaidi, M. Raza, Soboloff, Jonathan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4991353/
https://www.ncbi.nlm.nih.gov/pubmed/27417567
http://dx.doi.org/10.1007/s11427-016-5087-5
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author Hooper, Robert
Zaidi, M. Raza
Soboloff, Jonathan
author_facet Hooper, Robert
Zaidi, M. Raza
Soboloff, Jonathan
author_sort Hooper, Robert
collection PubMed
description Calcium is a key regulator of many physiological processes that are perturbed in cancer, such as migration, proliferation and apoptosis. The proteins STIM and Orai mediate store-operated calcium entry (SOCE), the main pathway for calcium entry in non-excitable cells. Changes in the expression and function of STIM and Orai have been found in a range of cancer types and thus implicated in disease progression. Here we discuss the role of STIM, Orai and the SOCE pathway in the progression of melanoma and explore how the heterogeneous nature of melanoma may explain the lack of consensus in the field regarding the role of SOCE in the progression of this disease.
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spelling pubmed-49913532016-08-19 The heterogeneity of store-operated calcium entry in melanoma Hooper, Robert Zaidi, M. Raza Soboloff, Jonathan Sci China Life Sci Article Calcium is a key regulator of many physiological processes that are perturbed in cancer, such as migration, proliferation and apoptosis. The proteins STIM and Orai mediate store-operated calcium entry (SOCE), the main pathway for calcium entry in non-excitable cells. Changes in the expression and function of STIM and Orai have been found in a range of cancer types and thus implicated in disease progression. Here we discuss the role of STIM, Orai and the SOCE pathway in the progression of melanoma and explore how the heterogeneous nature of melanoma may explain the lack of consensus in the field regarding the role of SOCE in the progression of this disease. 2016-07-14 2016-08 /pmc/articles/PMC4991353/ /pubmed/27417567 http://dx.doi.org/10.1007/s11427-016-5087-5 Text en http://creativecommons.org/licenses/by/4.0/ Open Access This article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution, and reproduction in any medium, provided the original author(s) and source are credited.
spellingShingle Article
Hooper, Robert
Zaidi, M. Raza
Soboloff, Jonathan
The heterogeneity of store-operated calcium entry in melanoma
title The heterogeneity of store-operated calcium entry in melanoma
title_full The heterogeneity of store-operated calcium entry in melanoma
title_fullStr The heterogeneity of store-operated calcium entry in melanoma
title_full_unstemmed The heterogeneity of store-operated calcium entry in melanoma
title_short The heterogeneity of store-operated calcium entry in melanoma
title_sort heterogeneity of store-operated calcium entry in melanoma
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4991353/
https://www.ncbi.nlm.nih.gov/pubmed/27417567
http://dx.doi.org/10.1007/s11427-016-5087-5
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