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RNA methyltransferase NSUN2 promotes stress-induced HUVEC senescence

The tRNA methyltransferase NSUN2 delays replicative senescence by regulating the translation of CDK1 and CDKN1B mRNAs. However, whether NSUN2 influences premature cellular senescence remains untested. Here we show that NSUN2 methylates SHC mRNA in vitro and in cells, thereby enhancing the translatio...

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Detalles Bibliográficos
Autores principales:	Cai, Xiaoyu, Hu, Yuanyuan, Tang, Hao, Hu, Han, Pang, Lijun, Xing, Junyue, Liu, Zhenyun, Luo, Yuhong, Jiang, Bin, Liu, Te, Gorospe, Myriam, Chen, Chuan, Wang, Wengong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2016
Materias:	Research Paper: Gerotarget (Focus on Aging)
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4991368/ https://www.ncbi.nlm.nih.gov/pubmed/26992231 http://dx.doi.org/10.18632/oncotarget.8087

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