Cargando…

Dopamine D(2) gene expression interacts with environmental enrichment to impact lifespan and behavior

Aging produces cellular, molecular, and behavioral changes affecting many areas of the brain. The dopamine (DA) system is known to be vulnerable to the effects of aging, which regulate behavioral functions such as locomotor activity, body weight, and reward and cognition. In particular, age-related...

Descripción completa

Detalles Bibliográficos
Autores principales:	Thanos, Panayotis K., Hamilton, John, O'Rourke, Joseph R., Napoli, Anthony, Febo, Marcelo, Volkow, Nora D., Blum, Kenneth, Gold, Mark
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2016
Materias:	Research Paper: Gerotarget (Focus on Aging)
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4991369/ https://www.ncbi.nlm.nih.gov/pubmed/26992232 http://dx.doi.org/10.18632/oncotarget.8088

Ejemplares similares

Clinically Combating Reward Deficiency Syndrome (RDS) with Dopamine Agonist Therapy as a Paradigm Shift: Dopamine for Dinner?
por: Blum, Kenneth, et al.
Publicado: (2015)

Variation of lifespan in multiple strains, and effects of dietary restriction and BmFoxO on lifespan in silkworm, Bombyx mori
por: Song, Jiangbo, et al.
Publicado: (2016)

Length of paternal lifespan is manifested in the DNA methylome of their nonagenarian progeny
por: Marttila, Saara, et al.
Publicado: (2015)

Bmk-1 regulates lifespan in Caenorhabditis elegans by activating hsp-16
por: Qian, Hong, et al.
Publicado: (2015)

Epigallocatechin gallate affects glucose metabolism and increases fitness and lifespan in Drosophila melanogaster
por: Wagner, Anika E., et al.
Publicado: (2015)

GDF11 administration does not extend lifespan in a mouse model of premature aging
por: Freitas-Rodríguez, Sandra, et al.
Publicado: (2016)

Stress resistance and lifespan are increased in C. elegans but decreased in S. cerevisiae by mafr-1/maf1 deletion
por: Cai, Ying, et al.
Publicado: (2016)

Towards understanding the lifespan extension by reduced insulin signaling: bioinformatics analysis of DAF-16/FOXO direct targets in Caenorhabditis elegans
por: Li, Yan-Hui, et al.
Publicado: (2016)

Aging-related dysregulation in enteric dopamine and angiotensin system interactions: implications for gastrointestinal dysfunction in the elderly
por: Garrido-Gil, Pablo, et al.
Publicado: (2018)

Combined effects of aging and inflammation on renin-angiotensin system mediate mitochondrial dysfunction and phenotypic changes in cardiomyopathies
por: Burks, Tyesha N., et al.
Publicado: (2015)

Caloric restriction extends yeast chronological lifespan via a mechanism linking cellular aging to cell cycle regulation, maintenance of a quiescent state, entry into a non-quiescent state and survival in the non-quiescent state
por: Leonov, Anna, et al.
Publicado: (2017)

Dopamine and glucose, obesity, and reward deficiency syndrome
por: Blum, Kenneth, et al.
Publicado: (2014)

Improved muscle function and quality after diet intervention with leucine-enriched whey and antioxidants in antioxidant deficient aged mice
por: van Dijk, Miriam, et al.
Publicado: (2016)

DNA damage response (DDR) and senescence: shuttled inflamma-miRNAs on the stage of inflamm-aging
por: Olivieri, Fabiola, et al.
Publicado: (2015)

Rapid and simple detection of gero-suppressive agents
por: Darzynkiewicz, Zbigniew
Publicado: (2015)

WW domain-containing oxidoreductase in neuronal injury and neurological diseases
por: Chang, Hsin-Tzu, et al.
Publicado: (2014)

Understanding the gastrointestinal tract of the elderly to develop dietary solutions that prevent malnutrition
por: Rémond, Didier, et al.
Publicado: (2015)

Measuring refractive index distribution in the human eye lens
por: Pope, James M., et al.
Publicado: (2015)

Characterization and redox mechanism of asthma in the elderly
por: Zuo, Li, et al.
Publicado: (2016)

REM sleep behaviour disorder (RBD): risk for Parkinsonism and executive dysfunction in elderly
por: Lerche, Stefanie, et al.
Publicado: (2018)

TGF-β1-Smad signaling pathways are not required for epidermal LC homeostasis
por: Li, Guihua, et al.
Publicado: (2016)

Reprogramming of energy metabolism as a driver of aging
por: Feng, Zhaoyang, et al.
Publicado: (2016)

Effects of circadian clock genes and environmental factors on cognitive aging in old adults in a Taiwanese population
por: Lin, Eugene, et al.
Publicado: (2017)

Up-regulation of serotonin receptor 2B mRNA and protein in the peri-infarcted area of aged rats and stroke patients
por: Buga, Ana-Maria, et al.
Publicado: (2016)

Environmental tobacco smoke increases autophagic effects but decreases longevity associated with Sirt-1 protein expression in young C57BL mice hearts
por: Ting, Wei-Jen, et al.
Publicado: (2016)

Epigenetic clock analyses of cellular senescence and ageing
por: Lowe, Donna, et al.
Publicado: (2016)

BTLA expression declines on B cells of the aged and is associated with low responsiveness to the trivalent influenza vaccine
por: Kannan, Senthil, et al.
Publicado: (2015)

Quantifying signaling pathway activation to monitor the quality of induced pluripotent stem cells
por: Makarev, Eugene, et al.
Publicado: (2015)

Specific changes in mitochondrial lipidome alter mitochondrial proteome and increase the geroprotective efficiency of lithocholic acid in chronologically aging yeast
por: Leonov, Anna, et al.
Publicado: (2017)

Age and metabolic risk factors associated with oxidatively damaged DNA in human peripheral blood mononuclear cells
por: Løhr, Mille, et al.
Publicado: (2014)

Trafficking protein particle complex 6A delta (TRAPPC6AΔ) is an extracellular plaque-forming protein in the brain
por: Chang, Jean-Yun, et al.
Publicado: (2015)

Plasmid DNA-coding p62 as a bone effective anti-inflammatory/anabolic agent
por: Sabbieti, Maria Giovanna, et al.
Publicado: (2015)

Non-coding genomic regions possessing enhancer and silencer potential are associated with healthy aging and exceptional survival
por: Kim, Sangkyu, et al.
Publicado: (2015)

The function of cux1 in oxidative dna damage repair is needed to prevent premature senescence of mouse embryo fibroblasts
por: Ramdzan, Zubaidah M., et al.
Publicado: (2015)

DNA methylome and transcriptome sequencing in human ovarian granulosa cells links age-related changes in gene expression to gene body methylation and 3ʹ-end GC density
por: Yu, Bo, et al.
Publicado: (2015)

Autophagy through 4EBP1 and AMPK regulates oxidative stress-induced premature senescence in auditory cells
por: Tsuchihashi, Nana Akagi, et al.
Publicado: (2014)

Ammonium is a key determinant on the dietary restriction of yeast chronological aging in culture medium
por: Santos, Júlia, et al.
Publicado: (2014)

Immunostimulatory effects of RACK1 pseudosubstrate in human leukocytes obtained from young and old donors
por: Corsini, Emanuela, et al.
Publicado: (2015)

Systemic attenuation of the TGF-β pathway by a single drug simultaneously rejuvenates hippocampal neurogenesis and myogenesis in the same old mammal
por: Yousef, Hanadie, et al.
Publicado: (2015)

EGCG-mediated autophagy flux has a neuroprotection effect via a class III histone deacetylase in primary neuron cells
por: Lee, Ju-Hee, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_hdvlpdpble8ghbf22dscbte55v