Cargando…
The cytoskeletal arrangements necessary to neurogenesis
During the process of neurogenesis, the stem cell committed to the neuronal cell fate starts a series of molecular and morphological changes. The understanding of the physio-pathology of mechanisms controlling the molecular and morphological changes occurring during neuronal differentiation is funda...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Impact Journals LLC
2016
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4991392/ https://www.ncbi.nlm.nih.gov/pubmed/26760504 http://dx.doi.org/10.18632/oncotarget.6838 |
_version_ | 1782448848582475776 |
---|---|
author | Compagnucci, Claudia Piemonte, Fiorella Sferra, Antonella Piermarini, Emanuela Bertini, Enrico |
author_facet | Compagnucci, Claudia Piemonte, Fiorella Sferra, Antonella Piermarini, Emanuela Bertini, Enrico |
author_sort | Compagnucci, Claudia |
collection | PubMed |
description | During the process of neurogenesis, the stem cell committed to the neuronal cell fate starts a series of molecular and morphological changes. The understanding of the physio-pathology of mechanisms controlling the molecular and morphological changes occurring during neuronal differentiation is fundamental to the development of effective therapies for many neurologic diseases. Unfortunately, our knowledge of the biological events occurring in the cell during neuronal differentiation is still poor. In this study, we focus preliminarily on the relevance of the cytoskeletal rearrangements, which earlier drive the morphology of the neuronal precursors, and later the migrating/mature neurons. In fact, neuritogenesis, neurite branching, outgrowth and retraction are seminal to the development of a fully functional nervous system. With this in mind, we highlight the importance of iPSC technology to study the processes of cytoskeletal-driven morphological changes during neuronal differentiation. |
format | Online Article Text |
id | pubmed-4991392 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Impact Journals LLC |
record_format | MEDLINE/PubMed |
spelling | pubmed-49913922016-09-01 The cytoskeletal arrangements necessary to neurogenesis Compagnucci, Claudia Piemonte, Fiorella Sferra, Antonella Piermarini, Emanuela Bertini, Enrico Oncotarget Review During the process of neurogenesis, the stem cell committed to the neuronal cell fate starts a series of molecular and morphological changes. The understanding of the physio-pathology of mechanisms controlling the molecular and morphological changes occurring during neuronal differentiation is fundamental to the development of effective therapies for many neurologic diseases. Unfortunately, our knowledge of the biological events occurring in the cell during neuronal differentiation is still poor. In this study, we focus preliminarily on the relevance of the cytoskeletal rearrangements, which earlier drive the morphology of the neuronal precursors, and later the migrating/mature neurons. In fact, neuritogenesis, neurite branching, outgrowth and retraction are seminal to the development of a fully functional nervous system. With this in mind, we highlight the importance of iPSC technology to study the processes of cytoskeletal-driven morphological changes during neuronal differentiation. Impact Journals LLC 2016-01-07 /pmc/articles/PMC4991392/ /pubmed/26760504 http://dx.doi.org/10.18632/oncotarget.6838 Text en Copyright: © 2016 Compagnucci et al. http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Review Compagnucci, Claudia Piemonte, Fiorella Sferra, Antonella Piermarini, Emanuela Bertini, Enrico The cytoskeletal arrangements necessary to neurogenesis |
title | The cytoskeletal arrangements necessary to neurogenesis |
title_full | The cytoskeletal arrangements necessary to neurogenesis |
title_fullStr | The cytoskeletal arrangements necessary to neurogenesis |
title_full_unstemmed | The cytoskeletal arrangements necessary to neurogenesis |
title_short | The cytoskeletal arrangements necessary to neurogenesis |
title_sort | cytoskeletal arrangements necessary to neurogenesis |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4991392/ https://www.ncbi.nlm.nih.gov/pubmed/26760504 http://dx.doi.org/10.18632/oncotarget.6838 |
work_keys_str_mv | AT compagnucciclaudia thecytoskeletalarrangementsnecessarytoneurogenesis AT piemontefiorella thecytoskeletalarrangementsnecessarytoneurogenesis AT sferraantonella thecytoskeletalarrangementsnecessarytoneurogenesis AT piermariniemanuela thecytoskeletalarrangementsnecessarytoneurogenesis AT bertinienrico thecytoskeletalarrangementsnecessarytoneurogenesis AT compagnucciclaudia cytoskeletalarrangementsnecessarytoneurogenesis AT piemontefiorella cytoskeletalarrangementsnecessarytoneurogenesis AT sferraantonella cytoskeletalarrangementsnecessarytoneurogenesis AT piermariniemanuela cytoskeletalarrangementsnecessarytoneurogenesis AT bertinienrico cytoskeletalarrangementsnecessarytoneurogenesis |