Amyloid precursor protein and amyloid precursor-like protein 2 in cancer

Amyloid precursor protein (APP) and its family members amyloid precursor-like protein 1 (APLP1) and amyloid precursor-like protein 2 (APLP2) are type 1 transmembrane glycoproteins that are highly conserved across species. The transcriptional regulation of APP and APLP2 is similar but not identical,...

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Autores principales: Pandey, Poomy, Sliker, Bailee, Peters, Haley L., Tuli, Amit, Herskovitz, Jonathan, Smits, Kaitlin, Purohit, Abhilasha, Singh, Rakesh K., Dong, Jixin, Batra, Surinder K., Coulter, Donald W., Solheim, Joyce C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4991393/
https://www.ncbi.nlm.nih.gov/pubmed/26840089
http://dx.doi.org/10.18632/oncotarget.7103
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author Pandey, Poomy
Sliker, Bailee
Peters, Haley L.
Tuli, Amit
Herskovitz, Jonathan
Smits, Kaitlin
Purohit, Abhilasha
Singh, Rakesh K.
Dong, Jixin
Batra, Surinder K.
Coulter, Donald W.
Solheim, Joyce C.
author_facet Pandey, Poomy
Sliker, Bailee
Peters, Haley L.
Tuli, Amit
Herskovitz, Jonathan
Smits, Kaitlin
Purohit, Abhilasha
Singh, Rakesh K.
Dong, Jixin
Batra, Surinder K.
Coulter, Donald W.
Solheim, Joyce C.
author_sort Pandey, Poomy
collection PubMed
description Amyloid precursor protein (APP) and its family members amyloid precursor-like protein 1 (APLP1) and amyloid precursor-like protein 2 (APLP2) are type 1 transmembrane glycoproteins that are highly conserved across species. The transcriptional regulation of APP and APLP2 is similar but not identical, and the cleavage of both proteins is regulated by phosphorylation. APP has been implicated in Alzheimer's disease causation, and in addition to its importance in neurology, APP is deregulated in cancer cells. APLP2 is likewise overexpressed in cancer cells, and APLP2 and APP are linked to increased tumor cell proliferation, migration, and invasion. In this present review, we discuss the unfolding account of these APP family members’ roles in cancer progression and metastasis.
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spelling pubmed-49913932016-09-01 Amyloid precursor protein and amyloid precursor-like protein 2 in cancer Pandey, Poomy Sliker, Bailee Peters, Haley L. Tuli, Amit Herskovitz, Jonathan Smits, Kaitlin Purohit, Abhilasha Singh, Rakesh K. Dong, Jixin Batra, Surinder K. Coulter, Donald W. Solheim, Joyce C. Oncotarget Review Amyloid precursor protein (APP) and its family members amyloid precursor-like protein 1 (APLP1) and amyloid precursor-like protein 2 (APLP2) are type 1 transmembrane glycoproteins that are highly conserved across species. The transcriptional regulation of APP and APLP2 is similar but not identical, and the cleavage of both proteins is regulated by phosphorylation. APP has been implicated in Alzheimer's disease causation, and in addition to its importance in neurology, APP is deregulated in cancer cells. APLP2 is likewise overexpressed in cancer cells, and APLP2 and APP are linked to increased tumor cell proliferation, migration, and invasion. In this present review, we discuss the unfolding account of these APP family members’ roles in cancer progression and metastasis. Impact Journals LLC 2016-01-31 /pmc/articles/PMC4991393/ /pubmed/26840089 http://dx.doi.org/10.18632/oncotarget.7103 Text en Copyright: © 2016 Pandey et al. http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Review
Pandey, Poomy
Sliker, Bailee
Peters, Haley L.
Tuli, Amit
Herskovitz, Jonathan
Smits, Kaitlin
Purohit, Abhilasha
Singh, Rakesh K.
Dong, Jixin
Batra, Surinder K.
Coulter, Donald W.
Solheim, Joyce C.
Amyloid precursor protein and amyloid precursor-like protein 2 in cancer
title Amyloid precursor protein and amyloid precursor-like protein 2 in cancer
title_full Amyloid precursor protein and amyloid precursor-like protein 2 in cancer
title_fullStr Amyloid precursor protein and amyloid precursor-like protein 2 in cancer
title_full_unstemmed Amyloid precursor protein and amyloid precursor-like protein 2 in cancer
title_short Amyloid precursor protein and amyloid precursor-like protein 2 in cancer
title_sort amyloid precursor protein and amyloid precursor-like protein 2 in cancer
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4991393/
https://www.ncbi.nlm.nih.gov/pubmed/26840089
http://dx.doi.org/10.18632/oncotarget.7103
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