The CNGRC-GG-(D)(KLAKLAK)(2) peptide induces a caspase-independent, Ca(2+)-dependent death in human leukemic myeloid cells by targeting surface aminopeptidase N/CD13

The CD13 antigen's binding site for the Asn-Gly-Arg (NGR) motif enables NGR-containing chemotherapeutic drugs to be delivered to CD13-positive tumours. Human CD13-positive acute myeloid leukemia (AML) cells proliferate abnormally and escape death. Here, we show that the CNGRC-GG-(D)(KLAKLAK)(2)...

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Detalles Bibliográficos
Autores principales: Bouchet, Sandrine, Tang, Ruoping, Fava, Fanny, Legrand, Ollivier, Bauvois, Brigitte
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2015
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4991394/
https://www.ncbi.nlm.nih.gov/pubmed/26655501
http://dx.doi.org/10.18632/oncotarget.6523

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4991394/
https://www.ncbi.nlm.nih.gov/pubmed/26655501
http://dx.doi.org/10.18632/oncotarget.6523

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