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The CNGRC-GG-(D)(KLAKLAK)(2) peptide induces a caspase-independent, Ca(2+)-dependent death in human leukemic myeloid cells by targeting surface aminopeptidase N/CD13
The CD13 antigen's binding site for the Asn-Gly-Arg (NGR) motif enables NGR-containing chemotherapeutic drugs to be delivered to CD13-positive tumours. Human CD13-positive acute myeloid leukemia (AML) cells proliferate abnormally and escape death. Here, we show that the CNGRC-GG-(D)(KLAKLAK)(2)...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Impact Journals LLC
2015
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4991394/ https://www.ncbi.nlm.nih.gov/pubmed/26655501 http://dx.doi.org/10.18632/oncotarget.6523 |